Cited 1 time in webofscience Cited 2 time in scopus

Optimized Halbach array for focused magnetic drug targeting

Title
Optimized Halbach array for focused magnetic drug targeting
Authors
Kee, HyeonwooLee, HyoryongPark, Sukho
DGIST Authors
Kee, Hyeonwoo; Lee, Hyoryong; Park, Sukho
Issue Date
2020-11
Citation
Journal of Magnetism and Magnetic Materials, 514, 167180
Type
Article
Article Type
Article
Author Keywords
Magnetic drug targetingHalbach arrayMagnetic nanoparticlePermanent magnetic sourceOptimization
Keywords
IRON-OXIDE NANOPARTICLESIN-VIVODELIVERYBIODISTRIBUTIONSYSTEM
ISSN
0304-8853
Abstract
Magnetic drug targeting (MDT) is a therapeutic method that delivers drug carriers containing magnetic nanoparticles to a target lesion by directing them using an external magnetic field. To minimize the possible side effects on the surrounding normal cells, focused magnetic drug targeting (FMDT) has been introduced, which allows drug carriers to be delivered only to the target lesions. FMDT, with its capability for local focusing and wide attraction, aims for highly efficient and concentrated drug delivery. In this study, a modified quasi-axisymmetric Halbach array design was introduced as an external magnetic source to perform FMDT. The proposed Halbach array design has a simple structure that is easy to assemble, unlike earlier Halbach array designs. The optimized Halbach array is fabricated as a result of the optimization of the magnetic force magnitude and local focusing with wide attraction using finite element method (FEM) analysis. Through simulations and experiments, the optimized Halbach array design is validated and a comparative analysis with other magnet types is performed. As a result, the optimization of the Halbach array using FEM is experimentally validated, and it is confirmed that the optimized Halbach array is more effective for FMDT than the permanent magnet used in MDT. © 2020 Elsevier B.V.
URI
http://hdl.handle.net/20.500.11750/12689
DOI
10.1016/j.jmmm.2020.167180
Publisher
Elsevier BV
Related Researcher
  • Author Park, Sukho Multiscale Biomedical Robotics Laboratory
  • Research Interests Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringMultiscale Biomedical Robotics Laboratory1. Journal Articles


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