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dc.contributor.author Kim, Bokyung -
dc.contributor.author Kim, Jin Hae -
dc.date.accessioned 2021-01-22T07:16:37Z -
dc.date.available 2021-01-22T07:16:37Z -
dc.date.created 2020-09-24 -
dc.date.created 2020-09-24 -
dc.date.created 2020-09-24 -
dc.date.issued 2020-09 -
dc.identifier.citation Journal of the Korean Magnetic Resonance Society, v.24, no.3, pp.86 - 90 -
dc.identifier.issn 1226-6531 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/12715 -
dc.description.abstract Iron-sulfur (Fe-S) clusters are one of the most ancient yet essential cofactors mediating various essential biological processes. In prokaryotes, Fe-S clusters are generated via several distinctive biogenesis mechanisms, among which the ISC (Iron-Sulfur Cluster) mechanism plays a house-keeping role to satisfy cellular needs for Fe-S clusters. The Escherichia coli ISC mechanism is maintained by several essential protein factors, whose structural characterization has been of great interest to reveal mechanistic details of the Fe-S cluster biogenesis mechanisms. In particular, nuclear magnetic resonance (NMR) spectroscopic approaches have contributed much to elucidate dynamic features not only in the structural states of the protein components but also in the interaction between them. The present minireview discusses recent advances in elucidating structural features of IscU, the key player in the E. coli ISC mechanism. IscU accommodates exceptional structural flexibility for its versatile activities, for which NMR spectroscopy was particularly successful. We expect that understanding to the structural diversity of IscU provides critical insight to appreciate functional versatility of the Fe-S cluster biogenesis mechanism. -
dc.language English -
dc.publisher 한국자기공명학회 -
dc.title Structural flexibility of Escherichia coli IscU, the iron-sulfur cluster scaffold protein -
dc.type Article -
dc.identifier.doi 10.6564/JKMRS.2020.24.3.086 -
dc.identifier.wosid 000588490200004 -
dc.type.local Article(Domestic) -
dc.type.rims ART -
dc.description.journalClass 2 -
dc.citation.publicationname Journal of the Korean Magnetic Resonance Society -
dc.identifier.kciid ART002625793 -
dc.contributor.localauthor Kim, Bokyung -
dc.contributor.localauthor Kim, Jin Hae -
dc.contributor.nonIdAuthor Kim, Bokyung -
dc.identifier.citationVolume 24 -
dc.identifier.citationNumber 3 -
dc.identifier.citationStartPage 86 -
dc.identifier.citationEndPage 90 -
dc.identifier.citationTitle Journal of the Korean Magnetic Resonance Society -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor NMR spectroscopy -
dc.subject.keywordAuthor iron-sulfur cluster -
dc.subject.keywordAuthor iron-sulfur cluster biogenesis -
dc.subject.keywordAuthor protein structure -
dc.subject.keywordAuthor protein dynamics -


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