Cited 2 time in webofscience Cited 2 time in scopus

Noble metal sensitized invasive porous bioelectrodes: Advanced medical device for enhanced neuronal activity and chronic alcohol treatment

Title
Noble metal sensitized invasive porous bioelectrodes: Advanced medical device for enhanced neuronal activity and chronic alcohol treatment
Authors
Kim, Hong SooChoi, HansaemFlores, Monica ClaireRazzaq, AbdulGwak, Young SeobAhn, DanbiKim, Mi SeonGurel, OganLee, Bong HyoIn, Su-Il
DGIST Authors
Kim, Hong Soo; Choi, Hansaem; Flores, Monica Claire; Razzaq, Abdul; Gwak, Young Seob; Ahn, Danbi; Kim, Mi Seon; Gurel, Ogan; Lee, Bong Hyo; In, Su-Il
Issue Date
2020-12
Citation
RSC Advances, 10(71), 43514-43522
Type
Article
Article Type
Article
Keywords
DE-QIMECHANISMEVOLUTIONACUPOINTSTISSUESENSORFUNCTIONALIZED ACUPUNCTURE NEEDLEANXIETY-LIKE BEHAVIORPLATINUM NANOPARTICLESMYOFASCIAL PAIN
ISSN
2046-2069
Abstract
Invasive bioelectrodes are widely used as an effective treatment for several acute and chronic diseases. In earlier work using high surface area invasive porous bioelectrodes evaluated in an animal model of alcoholism withdrawal, we demonstrated significantly improved electrophysiological and behavioral responses. In this study, we further modify the surface of these invasive porous bioelectrodes with noble metal (Ag, Au, Pt) nanoparticles. Compared to both conventional and porous bioelectrodes, noble metal sensitized invasive porous bioelectrodes show markedly increased low threshold (LT) and wide dynamic range (WDR) neuronal activity. In particular, Pt-sensitized invasive porous bioelectrodes show the highest WDR neuronal activity only upon insertion. In addition, Ag-sensitized invasive porous bioelectrodes, whose surface area is about 37 times greater than that of conventional bioelectrodes, show improved electrochemical properties with higher LT and WDR neuronal activity when stimulated. In an animal model of chronic alcoholism, using normal and alcohol-treated Sprague-Dawley (SD) rats evaluated with the elevated plus maze (EPM) test, the Ag-sensitized invasive porous bioelectrodes show about 20% higher open arms time. These results suggest that these noble metal-sensitized invasive bioelectrodes may offer improved therapeutic outcomes for the treatment of chronic alcoholism, and given these enhanced electrophysiological properties, for other conditions as well. This journal is © The Royal Society of Chemistry.
URI
http://hdl.handle.net/20.500.11750/12723
DOI
10.1039/d0ra07922g
Publisher
Royal Society of Chemistry
Related Researcher
  • Author In, Su-Il Green and Renewable Energy for Endless Nature(GREEN) Lab
  • Research Interests CO2 conversion to hydrocarbon fuels; Water splitting for hydrogen generation; Quantum dot devices; Dye sensitized solar cells; Environmental remediation; Synthesis of functional nanomaterials; CO2 연료전환; 수소생산을 위한 광전기화학적 물분해; 양자점 태양전지; 염료감응 태양전지; 공해물질 저감연구; 기능성 나노소재 개발
Files:
Collection:
Department of Energy Science and EngineeringGreen and Renewable Energy for Endless Nature(GREEN) Lab1. Journal Articles


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