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Gait Disturbance Improvement and Cerebral Cortex Rearrangement by Acupuncture in Parkinson’s Disease: A Pilot Assessor-Blinded, Randomized, Controlled, Parallel-Group Trial

Title
Gait Disturbance Improvement and Cerebral Cortex Rearrangement by Acupuncture in Parkinson’s Disease: A Pilot Assessor-Blinded, Randomized, Controlled, Parallel-Group Trial
Authors
Jang, Jung-HeePark, SangsooAn, JinungChoi, Jong-dukSeol, In ChanPark, GunhyukLee, Seung HyunMoon, YoungKang, WeechangJung, Eun-SunCha, Ji-yunKim, Chan-youngKim, SiyeonJung, In ChulYoo, Horyong
DGIST Authors
Jang, Jung-Hee; Park, Sangsoo; An, Jinung; Choi, Jong-duk; Seol, In Chan; Park, Gunhyuk; Lee, Seung Hyun; Moon, Young; Kang, Weechang; Jung, Eun-Sun; Cha, Ji-yun; Kim, Chan-young; Kim, Siyeon; Jung, In Chul; Yoo, Horyong
Issue Date
2020-12
Citation
Neurorehabilitation and Neural Repair, 34(12), 1111-1123
Type
Article
Article Type
Article
Author Keywords
Parkinson’s diseasegaitacupuncturenear infrared spectroscopy
ISSN
1545-9683
Abstract
Background: Parkinson’s disease (PD) leads to impaired mobility and limited independence. Objective: We investigated the effects of acupuncture on gait disturbance and analyzed hemodynamic changes caused by acupuncture in the cerebral cortex of patients with PD. Methods: Participants (n = 26) with gait disturbance due to PD were randomly assigned to the intervention (acupuncture twice a week for 4 weeks + conventional therapy) or control (conventional therapy) groups. We analyzed gait parameters using the GAITRite system and hemodynamic responses in the cerebral cortices using functional near-infrared spectroscopy, Unified Parkinson’s Disease Rating Scale (UPDRS) scores, neurotransmitter levels, as well as the immediate effects of acupuncture in patients with PD. Results: The participants tended to walk with hypometric gait (high cadence, short steps) overground. After acupuncture treatment, those in the intervention group showed a significant reduction in cadence and the UPDRS scores involving “walking and balance” compared with those in the control group (P =.004 and P =.020, respectively); the stride, swing, and single support times were significantly increased (P =.006, P =.001, and P =.001, respectively). Oxyhemoglobin levels in the intervention group while walking on a treadmill were significantly increased in the prefrontal and supplementary motor areas. The oxyhemoglobin levels in the prefrontal cortex and swing time revealed significant positive correlations. Conclusions: Our findings indicated that acupuncture tended to improve hypometric gait and rearranged activation of the cerebral cortex. Thus, acupuncture may be a useful complementary treatment for gait disturbance, including hypometric gait, in patients with PD. Trial Registration Number. Clinical Research Information Service (KCT0002603), https://cris.nih.go.kr/cris/index.jsp © The Author(s) 2020.
URI
http://hdl.handle.net/20.500.11750/12736
DOI
10.1177/1545968320969942
Publisher
Sage Science Press
Related Researcher
  • Author An, Jinung Brain Robot Augmented InteractioN(BRAIN) Laboratory
  • Research Interests
Files:
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Collection:
Division of Intelligent RoboticsBrain Robot Augmented InteractioN(BRAIN) Laboratory1. Journal Articles


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