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Tlr2 and the nlrp3 inflammasome mediate il-1β production in prevotella nigrescens-infected dendritic cells

Title
Tlr2 and the nlrp3 inflammasome mediate il-1β production in prevotella nigrescens-infected dendritic cells
Authors
Jang, Hye-MiPark, Ji-YeonLee, Yeon-JiKang, Min-JungJo, Sung-GangJeong, Yu-JinCho, Nam-PyoCho, Sung-DaeKim, Dong-JaePark, Jong-Hwan
Issue Date
2021-01
Citation
International Journal of Medical Sciences, 18(2), 432-440
Type
Article
Article Type
Article
Author Keywords
Prevotella nigrescensIL-1 betaTLR2NLRP3 inflammasomeBMDCs
Keywords
TOLL-LIKE RECEPTORSAGGREGATIBACTER-ACTINOMYCETEMCOMITANSFUSOBACTERIUM-NUCLEATUMP2X7 RECEPTORACTIVATIONINTERLEUKIN-1-BETACASPASE-1SECRETIONFLAGELLINDISEASE
ISSN
1449-1907
Abstract
Prevotella nigrescens is an oral pathogen that is frequently observed in the subgingival plaque of periodontitis patients. Interleukin-1β (IL-1β) is known to be involved in the immunopathology of periodontal diseases and has been implicated in the destruction of bone. In this study, we investigated the mechanism of IL-1β production by P. nigrescens in murine bone marrow-derived dendritic cells (BMDCs). Our results showed that a host receptor, Toll-like receptor 2 (TLR2), but not TLR4 is required for pro-IL-1β induction and nucleotide-binding oligomerization domain like receptor pyrin domain containing 3 (NLRP3) priming in BMDCs in response to P. nigrescens and activation of the NLRP3 inflammasome is necessary for processing of pro-IL-1β into mature IL-1β. In addition, an inhibitor assay revealed that production of reactive oxygen species, P2X7R activity, and release of cathepsin B are involved in IL-1β production in BMDCs in response to P. nigrescens. © The author(s).
URI
http://hdl.handle.net/20.500.11750/12748
DOI
10.7150/ijms.47197
Publisher
Ivyspring International Publisher
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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