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dc.contributor.author Lee, Joon-Hyuk -
dc.contributor.author Kim, Ji-young -
dc.contributor.author Noh, Seulgi -
dc.contributor.author Lee, Hyoeun -
dc.contributor.author Lee, Se Young -
dc.contributor.author Mun, Ji Young -
dc.contributor.author Park, Hyungju -
dc.contributor.author Chung, Won-Suk -
dc.date.accessioned 2021-01-22T07:28:55Z -
dc.date.available 2021-01-22T07:28:55Z -
dc.date.created 2021-01-14 -
dc.date.created 2021-01-14 -
dc.date.created 2021-01-14 -
dc.date.created 2021-01-14 -
dc.date.issued 2021-02 -
dc.identifier.citation Nature, v.590, no.7847, pp.612 - 617 -
dc.identifier.issn 0028-0836 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/12766 -
dc.description.abstract In the adult hippocampus, synapses are constantly formed and eliminated1,2. However, the exact function of synapse elimination in the adult brain, and how it is regulated, are largely unknown. Here we show that astrocytic phagocytosis3 is important for maintaining proper hippocampal synaptic connectivity and plasticity. By using fluorescent phagocytosis reporters, we find that excitatory and inhibitory synapses are eliminated by glial phagocytosis in the CA1 region of the adult mouse hippocampus. Unexpectedly, we found that astrocytes have a major role in the neuronal activity-dependent elimination of excitatory synapses. Furthermore, mice in which astrocytes lack the phagocytic receptor MEGF10 show a reduction in the elimination of excitatory synapses; as a result, excessive but functionally impaired synapses accumulate. Finally, Megf10-knockout mice show defective long-term synaptic plasticity and impaired formation of hippocampal memories. Together, our data provide strong evidence that astrocytes eliminate unnecessary excitatory synaptic connections in the adult hippocampus through MEGF10, and that this astrocytic function is crucial for maintaining circuit connectivity and thereby supporting cognitive function. © 2020, The Author(s), under exclusive licence to Springer Nature Limited. -
dc.language English -
dc.publisher Nature Publishing Group -
dc.title Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis -
dc.type Article -
dc.identifier.doi 10.1038/s41586-020-03060-3 -
dc.identifier.wosid 000601526800004 -
dc.identifier.scopusid 2-s2.0-85099499714 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Nature -
dc.contributor.localauthor Lee, Joon-Hyuk -
dc.contributor.localauthor Kim, Ji-young -
dc.contributor.localauthor Noh, Seulgi -
dc.contributor.localauthor Lee, Hyoeun -
dc.contributor.localauthor Lee, Se Young -
dc.contributor.localauthor Mun, Ji Young -
dc.contributor.localauthor Park, Hyungju -
dc.contributor.localauthor Chung, Won-Suk -
dc.contributor.nonIdAuthor Lee, Joon-Hyuk -
dc.contributor.nonIdAuthor Kim, Ji-young -
dc.contributor.nonIdAuthor Noh, Seulgi -
dc.contributor.nonIdAuthor Lee, Hyoeun -
dc.contributor.nonIdAuthor Lee, Se Young -
dc.contributor.nonIdAuthor Mun, Ji Young -
dc.contributor.nonIdAuthor Park, Hyungju -
dc.contributor.nonIdAuthor Chung, Won-Suk -
dc.identifier.citationVolume 590 -
dc.identifier.citationNumber 7847 -
dc.identifier.citationStartPage 612 -
dc.identifier.citationEndPage 617 -
dc.identifier.citationTitle Nature -
dc.type.journalArticle Article; Early Access -
dc.description.isOpenAccess N -
dc.subject.keywordPlus MICROGLIA -
dc.subject.keywordPlus POOL -
dc.subject.keywordPlus ELIMINATION -
dc.subject.keywordPlus PLASTICITY -

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