In point-based registration between the patient and the image, skin-affixed markers are attached to the patient’s skin. Although registration accuracy is relatively high in the region around the markers. The accuracy decreases at a deeply seated target in the body, in proportion to the distance from the surface where the markers are attached. To decrease target registration error (TRE) around the target rather than fiducial registration error (FRE) around the skin markers, additional points should be considered for the registration near the target organ. In this study, a method is proposed that uses an anatomical landmark around the target as an additional point for the registration to decrease TRE. ⓒ 2013 DGIST