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Elimination of Non-targeted Photoacoustic Signals for Combined Photoacoustic and Ultrasound Imaging

Title
Elimination of Non-targeted Photoacoustic Signals for Combined Photoacoustic and Ultrasound Imaging
Authors
Kim, HaeminLee, HohyeonKim, HyuncheolChang, Jin Ho
DGIST Authors
Kim, Haemin; Lee, Hohyeon; Kim, Hyuncheol; Chang, Jin Ho
Issue Date
2021-05
Citation
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 68(5), 1593-1604
Type
Article
Article Type
Article
Author Keywords
ImagingUltrasonic imagingSensitivityOptical sensorsOptical imagingLesionsBiomedical optical imagingBackground photoacoustic (PA) signal removaldual-modal imagingimage enhancementmultimodality fusionPA imagingultrasound (US)
Keywords
CONTRAST-ENHANCED ULTRASOUNDIN-VIVOINDOCYANINE-GREENBIOMEDICAL APPLICATIONSCARBON NANOTUBESDRUG-DELIVERYNANOPARTICLESMICROBUBBLESSYSTEMIDENTIFICATION
ISSN
0885-3010
Abstract
As a molecular imaging modality, photoacoustic imaging has been in the spotlight because it can provide an optical contrast image of physiological information and a relatively deep imaging depth. However, its sensitivity is limited despite the use of exogenous contrast agents due to the background photoacoustic signals generated from non-targeted absorbers such as blood and boundaries between different biological tissues. Additionally, clutter artifacts generated in both in-plane and out-of-plane imaging region degrade the sensitivity of photoacoustic imaging. We propose a method to eliminate the non-targeted photoacoustic signals. For this study, we used a dual-modal ultrasound-photoacoustic contrast agent that is capable of generating both backscattered ultrasound and photoacoustic signal in response to transmitted ultrasound and irradiated light, respectively. The ultrasound images of the contrast agents are used to construct a masking image that contains the location information about the target site and is applied to the photoacoustic image acquired after contrast agent injection. In-vitro and in-vivo experimental results demonstrated that the masking image constructed using the ultrasound images makes it possible to completely remove non-targeted photoacoustic signals. The proposed method can be used to enhance clear visualization of the target area in photoacoustic images. IEEE
URI
http://hdl.handle.net/20.500.11750/12822
DOI
10.1109/TUFFC.2020.3041634
Publisher
Institute of Electrical and Electronics Engineers
Related Researcher
  • Author Chang, Jin Ho Medical Acoustic Fusion Innovation Lab.
  • Research Interests Biomedical Imaging, Signal and Image Processing, Ultrasound Imaging System, Ultrasound Transducer, Photoacoustic Imaging
Files:
There are no files associated with this item.
Collection:
Department of Information and Communication EngineeringMedical Acoustic Fusion Innovation Lab.1. Journal Articles


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