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Acoustically Mediated Controlled Drug Release and Targeted Therapy with Degradable 3D Porous Magnetic Microrobots

Title
Acoustically Mediated Controlled Drug Release and Targeted Therapy with Degradable 3D Porous Magnetic Microrobots
Authors
Park, JongeonKim, Jin-youngPane, SalvadorNelson, Bradley J.Choi, Hongsoo
DGIST Authors
Park, Jongeon; Kim, Jin-young; Pane, Salvador; Nelson, Bradley J.; Choi, Hongsoo
Issue Date
2021-01
Citation
Advanced Healthcare Materials, 10(2), 2001096
Type
Article
Article Type
Article
Author Keywords
controlled releasemagnetic actuationmicrorobotstargeted therapyultrasound therapy
Keywords
FOCUSED ULTRASOUNDDELIVERYNANOMEDICINEFABRICATION
ISSN
2192-2640
Abstract
Microrobots for targeted drug delivery are of great interest due to their minimal invasiveness and wireless controllability. Here, a magnetically driven porous degradable microrobot (PDM) is reported that consists of a 3D printed helical soft polymeric chassis made of a poly(ethylene glycol) diacrylate and pentaerythritol triacrylate matrix containing magnetite nanoparticles and the anticancer drug 5-fluorouracil (5-FU). The encapsulated Fe3O4 nanoparticles render the PDM a precise wireless magnetic actuation by means of rotating magnetic fields (RMFs). The increased surface area of the porous PDM facilitates the acoustically induced drug release due to a higher response to the acoustic energy. The drug release profile from the PDM can be selected on command from three different modes, referred to herein as natural, burst, and constant, by differentiating the ultrasound exposure condition. Finally, in vitro test results reveal different therapeutic results for each release mode. The observed great reduction of cancer cell viability in the burst- and constant-release modes confirms that ultrasound with the proposed PDM can enhance the therapeutic effect by increasing drug concentration and sonoporation. © 2020 Wiley-VCH GmbH
URI
http://hdl.handle.net/20.500.11750/12932
DOI
10.1002/adhm.202001096
Publisher
Wiley-VCH Verlag
Related Researcher
Files:
There are no files associated with this item.
Collection:
Department of Robotics and Mechatronics EngineeringBio-Micro Robotics Lab1. Journal Articles


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