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Method for determining decrease in functions of hippocampus by using correlation between micro RNA and NMDA receptor, method for inhibiting decrease in functions, and method for screening for inhibitors of decrease in functions

Title
Method for determining decrease in functions of hippocampus by using correlation between micro RNA and NMDA receptor, method for inhibiting decrease in functions, and method for screening for inhibitors of decrease in functions
Translated Title
미세한 RNA와 NMDA 리셉터와 저지성 감소를 위한 방법 간의 상관 관계를 사용해 hippocampus의 기능에서 감소를 결정하기 위한 방법에서 기능 및 기능에서 감소의 억제제에 대해 가리기 위한 방법
Inventors
남홍길단카 찬드김기태
DGIST Inventors
남홍길; 단카 찬드; 김기태
Country
US
Application Date
2016-06-17
Application No.
15-736949
Registration Date
2020-07-07
Registration No.
10-704-099
Assignee
(재)대구경북과학기술원(50/0),기초과학연구원(50/100)
URI
http://hdl.handle.net/20.500.11750/13254
Abstract

The present invention relates to a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions. The present invention confirms that miR-204, among miRNAs up-regulated in an aged hippocampus, decreases the expression of EphB2, by accurately targeting EphB2, which is an important regulatory receptor, resulting in a decrease in the neuronal surface expression of an NR1 subunit of an NMDAR in hippocampal nerves and a decrease in the density of dendrites, thereby having an effect of determining whether the functions of the hippocampus are decreased, by using the correlation between a miRNA and an NMDAR, and furthermore, has an effect of providing a method for inhibiting the decrease in the functions of the hippocampus, and a method for screening for inhibitors of the decrease in the functions.

Related Researcher
  • Author Nam, Hong Gil CBRG(Complex Biology Research Group)
  • Research Interests Plant Aging and Life History; Systems Biology; Complexbiology; Comparative Aging Research
Files:
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Collection:
Department of New BiologyCBRG(Complex Biology Research Group)3. Patents


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