Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 남홍길 | - |
| dc.contributor.author | 단카 찬드 | - |
| dc.contributor.author | 김기태 | - |
| dc.date.accessioned | 2021-04-23T05:35:27Z | - |
| dc.date.available | 2021-04-23T05:35:27Z | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/13254 | - |
| dc.description.abstract | The present invention relates to a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions. The present invention confirms that miR-204, among miRNAs up-regulated in an aged hippocampus, decreases the expression of EphB2, by accurately targeting EphB2, which is an important regulatory receptor, resulting in a decrease in the neuronal surface expression of an NR1 subunit of an NMDAR in hippocampal nerves and a decrease in the density of dendrites, thereby having an effect of determining whether the functions of the hippocampus are decreased, by using the correlation between a miRNA and an NMDAR, and furthermore, has an effect of providing a method for inhibiting the decrease in the functions of the hippocampus, and a method for screening for inhibitors of the decrease in the functions. | - |
| dc.title | 마이크로 RNA와 NMDA 수용체의 상관관계를 이용한 해마의 기능감소 판단 방법, 기능감소 억제 방법 및 기능감소 억제제 스크리닝 방법 | - |
| dc.type | Patent | - |
| dc.publisher.country | US | - |
| dc.identifier.patentApplicationNumber | 15-736949 | - |
| dc.date.application | 2017-12-15 | - |
| dc.identifier.patentRegistrationNumber | 10-704-099 | - |
| dc.date.registration | 2020-07-07 | - |
| dc.contributor.assignee | (재)대구경북과학기술원(50/0),기초과학연구원(50/100) | - |
| dc.type.iprs | 특허 | - |
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