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dc.contributor.author Keum, Dong Il -
dc.contributor.author Suh, Byung Chang -
dc.date.accessioned 2021-04-23T09:02:33Z -
dc.date.available 2021-04-23T09:02:33Z -
dc.date.created 2018-03-29 -
dc.date.issued 2015 -
dc.identifier.citation Receptors & Clinical Investigation, v.2, no.1, pp.e515 - e515 -
dc.identifier.issn 2330-0566 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/13344 -
dc.description.abstract N-type voltage-gated Ca2+ (CaV2.2) channels, which enable synaptic transmission by triggering neurotransmitter release, are tightly modulated by G protein-coupled receptors (GPCRs) via several downstream signaling messengers, such as Gbg, calmodulin, arachidonic acid and PIP2. However, the molecular mechanism by which Gq/11-coupled receptors (GqPCRs) suppress CaV2.2 currents remains unclear. In this research highlight, we review our recent finding that M1 muscarinic receptors inhibit CaV2.2 channels through both Gbg-mediated voltage-dependent (VD) and Gαq/11/PLC-mediated voltage-independent (VI) pathways. Our photometry results also demonstrate that Gbg-mediated VD inhibition of CaV2.2 channels initiates approximately 3s earlier than VI inhibition, and is strongly potentiated in cells expressing plasma membrane-localized CaV b subunits. Our observations demonstrate a novel mechanism for CaV2.2 channel modulation by GqPCRs where the subcellular location of CaV b subunits plays a critical role in determining the voltage-dependence of current suppression by M1 receptors. -
dc.language English -
dc.publisher Smart Science & Technology LLC -
dc.title Molecular basis for N-type voltage-gated Ca2+ channel modulation by Gq protein-coupled receptors -
dc.type Article -
dc.identifier.doi 10.14800/rci.515 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Receptors & Clinical Investigation -
dc.contributor.nonIdAuthor Keum, Dong Il -
dc.identifier.citationVolume 2 -
dc.identifier.citationNumber 1 -
dc.identifier.citationStartPage e515 -
dc.identifier.citationEndPage e515 -
dc.identifier.citationTitle Receptors & Clinical Investigation -
dc.description.isOpenAccess N -
dc.contributor.affiliatedAuthor Keum, Dong Il -
dc.contributor.affiliatedAuthor Suh, Byung Chang -
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Department of Brain Sciences Laboratory of Brain Signal and Synapse Research 1. Journal Articles

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