Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Keum, Dong Il | - |
dc.contributor.author | Suh, Byung Chang | - |
dc.date.accessioned | 2021-04-23T09:02:33Z | - |
dc.date.available | 2021-04-23T09:02:33Z | - |
dc.date.created | 2018-03-29 | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Receptors & Clinical Investigation, v.2, no.1, pp.e515 - e515 | - |
dc.identifier.issn | 2330-0566 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/13344 | - |
dc.description.abstract | N-type voltage-gated Ca2+ (CaV2.2) channels, which enable synaptic transmission by triggering neurotransmitter release, are tightly modulated by G protein-coupled receptors (GPCRs) via several downstream signaling messengers, such as Gbg, calmodulin, arachidonic acid and PIP2. However, the molecular mechanism by which Gq/11-coupled receptors (GqPCRs) suppress CaV2.2 currents remains unclear. In this research highlight, we review our recent finding that M1 muscarinic receptors inhibit CaV2.2 channels through both Gbg-mediated voltage-dependent (VD) and Gαq/11/PLC-mediated voltage-independent (VI) pathways. Our photometry results also demonstrate that Gbg-mediated VD inhibition of CaV2.2 channels initiates approximately 3s earlier than VI inhibition, and is strongly potentiated in cells expressing plasma membrane-localized CaV b subunits. Our observations demonstrate a novel mechanism for CaV2.2 channel modulation by GqPCRs where the subcellular location of CaV b subunits plays a critical role in determining the voltage-dependence of current suppression by M1 receptors. | - |
dc.language | English | - |
dc.publisher | Smart Science & Technology LLC | - |
dc.title | Molecular basis for N-type voltage-gated Ca2+ channel modulation by Gq protein-coupled receptors | - |
dc.type | Article | - |
dc.identifier.doi | 10.14800/rci.515 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Receptors & Clinical Investigation | - |
dc.contributor.nonIdAuthor | Keum, Dong Il | - |
dc.identifier.citationVolume | 2 | - |
dc.identifier.citationNumber | 1 | - |
dc.identifier.citationStartPage | e515 | - |
dc.identifier.citationEndPage | e515 | - |
dc.identifier.citationTitle | Receptors & Clinical Investigation | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Keum, Dong Il | - |
dc.contributor.affiliatedAuthor | Suh, Byung Chang | - |
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