Cited 0 time in webofscience Cited 19 time in scopus

A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids

Title
A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids
Authors
Park, Jong-ChanJang, So-YeongLee, DongjoonLee, JeonghaKang, UiryongChang, HongjunKim, Haeng JunHan, Sun-HoSeo, JinsooChoi, MurimLee, Dong YoungByun, Min SooYi, DahyunCho, Kwang-HyunMook-Jung, Inhee
DGIST Authors
Park, Jong-Chan; Jang, So-Yeong; Lee, Dongjoon; Lee, Jeongha; Kang, Uiryong; Chang, Hongjun; Kim, Haeng Jun; Han, Sun-Ho; Seo, Jinsoo; Choi, Murim; Lee, Dong Young; Byun, Min Soo; Yi, Dahyun; Cho, Kwang-Hyun; Mook-Jung, Inhee
Issue Date
2021-01
Citation
Nature Communications, 12(1), 280
Type
Article
Keywords
braincell componentdrug developmentgenetic engineeringmedicinemental healthnervous system disorderpathology
ISSN
2041-1723
Abstract
Developing effective drugs for Alzheimer’s disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, we report an efficient, network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of AD with human iPSC-derived cerebral organoids (iCOs), including CRISPR-Cas9-edited isogenic lines. We use 1300 organoids from 11 participants to build a high-content screening (HCS) system and test blood–brain barrier-permeable FDA-approved drugs. Our study provides a strategy for precision medicine through the convergence of mathematical modeling and a miniature pathological brain model using iCOs. © 2021, The Author(s).
URI
http://hdl.handle.net/20.500.11750/13478
DOI
10.1038/s41467-020-20440-5
Publisher
Nature Publishing Group
Related Researcher
  • Author Seo, Jinsoo Laboratory of Aging Brain
  • Research Interests iPSC; Alzheimer's disease; Neurodegeneration; Synapse; Neuroscience
Files:
Collection:
Department of Brain SciencesLaboratory of Aging Brain1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE