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Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer

Title
Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer
Authors
Jang, JihunKim, JinwooLee, Hak JongChang, Jin Ho
DGIST Authors
Jang, Jihun; Kim, Jinwoo; Lee, Hak Jong; Chang, Jin Ho
Issue Date
2021-02
Citation
Sensors, 21(4), 1217
Type
Article
Author Keywords
transrectal probeoptical lensultrasound imagingphotoacoustic imagingprostate cancer
Keywords
Visual assessmentsProbesDiagnosisDiseasesFlexible electronicsImage enhancementOptical fibersOptical instrument lensesPrinted circuit boardsUltrasonicsUrologyAcoustic structuresFlexible printed circuit boardsIn-vivo experimentsMorphological changesOptical fiber bundlePhoto-acoustic imagingTransrectal ultrasound
ISSN
1424-8220
Abstract
A combined transrectal ultrasound and photoacoustic (TRUS–PA) imaging probe was developed for the clear visualization of morphological changes and microvasculature distribution in the prostate, as this is required for accurate diagnosis and biopsy. The probe consisted of a miniaturized 128-element 7 MHz convex array transducer with 134.5◦ field-of-view (FOV), a bifurcated optical fiber bundle, and two optical lenses. The design goal was to make the size of the TRUS–PA probe similar to that of general TRUS probes (i.e., about 20 mm), for the convenience of the patients. New flexible printed circuit board (FPCB), acoustic structure, and optical lens were developed to meet the requirement of the probe size, as well as to realize a high-performance TRUS–PA probe. In visual assessment, the PA signals obtained with the optical lens were 2.98 times higher than those without the lens. Moreover, the in vivo experiment with the xenograft BALB/c (Albino, Immunodeficient Inbred Strain) mouse model showed that TRUS–PA probe was able to acquire the entire PA image of the mouse tight behind the porcine intestine about 25 mm depth. From the ex vivo and in vivo experimental results, it can be concluded that the developed TRUS–PA probe is capable of improving PA image quality, even though the TRUS–PA probe has a cross-section size and an FOV comparable to those of general TRUS probes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/13497
DOI
10.3390/s21041217
Publisher
MDPI AG
Related Researcher
  • Author Chang, Jin Ho Medical Acoustic Fusion Innovation Lab.
  • Research Interests Biomedical Imaging, Signal and Image Processing, Ultrasound Imaging System, Ultrasound Transducer, Photoacoustic Imaging
Files:
Collection:
Department of Electrical Engineering and Computer ScienceMedical Acoustic Fusion Innovation Lab.1. Journal Articles


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