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Magnetophoretic Decoupler for Disaggregation and Interparticle Distance Control

Title
Magnetophoretic Decoupler for Disaggregation and Interparticle Distance Control
Authors
Kim, HyeonseolLim, ByeonghwaYoon, JonghwanKim, KeonmokTorati, Sri RamuluKim, CheolGi
DGIST Authors
Kim, Hyeonseol; Lim, Byeonghwa; Yoon, Jonghwan; Kim, Keonmok; Torati, Sri Ramulu; Kim, CheolGi
Issue Date
2021-06
Citation
Advanced Science, 8(12), 2100532
Type
Article
Author Keywords
bead pairdecouplerdisaggregationmagnetic fieldmagnetophoresiswave&#8208like pattern
ISSN
2198-3844
Abstract
The manipulation of superparamagnetic beads has attracted various lab on a chip and magnetic tweezer platforms for separating, sorting, and labeling cells and bioentities, but the irreversible aggregation of beads owing to magnetic interactions has limited its actual functionality. Here, an efficient solution is developed for the disaggregation of magnetic beads and interparticle distance control with a magnetophoretic decoupler using an external rotating magnetic field. A unique magnetic potential energy distribution in the form of an asymmetric magnetic thin film around the gap is created and tuned in a controlled manner, regulated by the size ratio of the bead with a magnetic pattern. Hence, the aggregated beads are detached into single beads and transported in one direction in an array pattern. Furthermore, the simultaneous and accurate spacing control of multiple magnetic bead pairs is performed by adjusting the angle of the rotating magnetic field, which continuously changes the energy well associated with a specific shape of the magnetic patterns. This technique offers an advanced solution for the disaggregation and controlled manipulation of beads, can allow new possibilities for the enhanced functioning of lab on a chip and magnetic tweezers platforms for biological assays, intercellular interactions, and magnetic biochip systems. © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH
URI
http://hdl.handle.net/20.500.11750/13758
DOI
10.1002/advs.202100532
Publisher
John Wiley and Sons Inc
Related Researcher
  • Author Kim, CheolGi Lab for NanoBio-MatErials & SpinTronics(nBEST)
  • Research Interests Magnetic Materials and Spintronics; Converging Technology of Nanomaterials and Biomaterials; Bio-NEMS;MEMS
Files:
Collection:
Department of Physics and ChemistryLab for NanoBio-Materials & SpinTronics(nBEST)1. Journal Articles


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