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Radioactive cesium removal by Prussian blue deposited iron oxide nanoparticles

Title
Radioactive cesium removal by Prussian blue deposited iron oxide nanoparticles
Authors
Faruque, Md Hasan AlChoi, Eun-SookKim, Jung-HeeKim, Eunjoo
DGIST Authors
Kim, Jung-Hee; Kim, Eunjoo
Issue Date
2019-11-01
Citation
2019 한국공업화학회 추계 총회 및 학술대회
Type
Conference
Abstract
Radioactive cesium removal by Prussian blue deposited iron oxide nanoparticles Hasan Al Faruque, Eun-Sook Choi, Jung-Hee Kim, Eunjoo Kim Companion Diagnostics and Medical Technology Research Group, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea, 42988 Prussian blue (PB), a most commonly used adsorbent for radioactive cesium (Cs) poisoning from several decades. However, multiple adverse effects limit its in vivo applications. Herein, to mitigate the side effects of Prussian Blue (PB), magnetic nanoparticle (M-NP)-based absorbents for cesium (Cs) was prepared by simple binding or photo-deposition of PB on iron oxide nanoparticles (M-PB-UV). The newly synthesized NPs were characterized and investigated for their cesium absorption properties in vitro. Moreover, the in vivo cesium removal efficiency of NPs was evaluated in C57BL/6 mice. An improved PB binding on the core of magnetite nanoparticle surface provided an increased absorbent capacity with reduced cytotoxicity on blood cells. Furthermore, better biocompatibility and increased Cs removal efficiency were observed in mice after daily oral administration. In addition, its repeated treatment did not show any alteration of the biochemical parameter of hepatic and renal functions as well as histology of major organs of the body during the experimental period. Taken together, PB-deposited magnetic nanoparticles may reduce the intake of potentially hazardous PB along with improved Cs removal capacity compare with the original form of the adsorbent.
URI
http://hdl.handle.net/20.500.11750/14202
Publisher
한국공업화학회
Related Researcher
  • Author Kim, Eunjoo  
  • Research Interests Biomarker, liquid biopsy, molecular diagnosis, nanobiosensor, drug delivery, exosome
Files:
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Collection:
Division of Electronics & Information System2. Conference Papers


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