Cited 0 time in webofscience Cited 0 time in scopus

Atmospheric pressure plasma assisted CW laser desorption source for imaging mass spectrometry applications

Title
Atmospheric pressure plasma assisted CW laser desorption source for imaging mass spectrometry applications
Authors
Kim, Jae YoungLee, SunYoungShin, Mi HyangLim, Dong-KwonPark, Ji-WonMoon, Dae Won
DGIST Authors
Kim, Jae Young; Moon, Dae Won
Issue Date
2018-06-20
Citation
28th SYMPOSIUM ON PLASMA PHYSICS AND TECHNOLOGY
Type
Conference
Abstract
We report a high spatial resolution ambient mass spectrometry (AP-MS) system that allows us to sensitively image live tissues at ambient environment. The method is based on an efficient desorption process by continuous wave (CW) laser assisted with nanoparticles and a subsequent ionization step by applying nonthermal helium plasma. The desorption of molecules from the tissues was found to be greatly enhanced by the strong photothermal effect of gold nanoparticles and CW laser. The subsequent ionization process with nonthermal atmospheric helium plasma jets enabled production of sufficient amounts of molecular ions of important molecules from live hippocampal tissues of an adult mouse. Combining the AP-MS with microscopic sample scanning, MS imaging with micrometer spatial resolution could be obtained with a sampling depth down to several tens of µm. This technique enables the advancement of AP-MS imaging technology into future clinical applications.
URI
http://hdl.handle.net/20.500.11750/14942
Publisher
INSTITUTE OF PLASMA PHYSICS, ACADEMY OF SCIENCES, PRAGUE, CZECH
Related Researcher
  • Author Moon, Dae Won NanoBio Imaging Laboratory
  • Research Interests Coherent Raman Scattering; Surface Plasmon Resonance Imaging Ellipsometry; Imaging Mass Spectrometry; Time-of-flight Medium Energy Ion Scattering
Files:
There are no files associated with this item.
Collection:
Department of Robotics and Mechatronics EngineeringRobotics Engineering Research Center2. Conference Papers
Department of New BiologyNanoBio Imaging Laboratory2. Conference Papers


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE