A multilayer networks analysis for mining quantification rules from big proteomics data

Abstract

Data modeling is important to understand and obtain the information from the data. Diverse designs can be developed for finding hidden information. Existing research in proteomics is limited in data modeling since only analysis of Protein–protein interaction (PPI) network is usually conducted. Here, we present a new approach for finding rules and bases to understand mechanisms of protein function. We build the multilayer network for integrating bottom-up proteomics data which is named TLP network. TLP network contains diverse biological information including the peptide expression data, and PTMs as well as Protein–protein interactions (PPIs). TLP network is expected to answer a wide range of questions in proteomics research area. ⓒ 2017 DGIST