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Nuclear VEGFR-2 Expression of Hepatocytes Is Involved in Hepatocyte Proliferation and Liver Regeneration During Chronic Liver Injury

Title
Nuclear VEGFR-2 Expression of Hepatocytes Is Involved in Hepatocyte Proliferation and Liver Regeneration During Chronic Liver Injury
Author(s)
Lee, A RangBaek, Su MinLee, Seoung WooKim, Tae UnHan, Jee EunBae, Seul GiPark, Sang JoonKim, Tae HwanJeong, Kyu ShikChoi, Seong-KyoonPark, Jin-Kyu
DGIST Authors
Lee, A RangBaek, Su MinLee, Seoung WooKim, Tae UnHan, Jee EunBae, Seul GiPark, Sang JoonKim, Tae HwanJeong, Kyu ShikChoi, Seong-KyoonPark, Jin-Kyu
Issued Date
2021-05
Type
Article
Author Keywords
VEGFR-2cell proliferationliver regenerationchronic liver diseaseintracellular location
Keywords
HEPATIC STELLATE CELLSSINUSOIDAL ENDOTHELIAL-CELLSPLASMA-PROTEINSHEPATOCELLULAR-CARCINOMASILICA NANOPARTICLESPHOSPHORYLATED KDRTARGETED DELIVERYSIZECHEMISTRYMEMBRANE
ISSN
0258-851X
Abstract
BACKGROUND/AIM: The pathological role of vascular endothelial growth factor receptor 2 (VEGFR-2) in chronic liver injury and liver regeneration is not fully understood. This study analysed the role of VEGFR-2 in liver fibrosis and its regeneration process. MATERIALS AND METHODS: We administered intraperitoneally 50 mg/kg to 300 mg/kg thioacetamide (TAA) to 9-week-old male mice for 17 weeks. We measured levels of VEGFR-2 protein and identified the location of cells that specifically express VEGFR-2. RESULTS: VEGFR-2 is rarely expressed in normal hepatocytes. However, high VEGFR-2 expression in liver sinusoidal endothelial cells was noted in the TAA group. Conversely, the group that experienced regeneration from liver fibrosis showed significantly higher VEGFR-2 expression in the nucleus of hepatocytes compared to the other groups. CONCLUSION: VEGFR-2 plays a pivotal role in the nucleus of hepatocytes during liver regeneration and VEGFR-2 may be closely related to cell division. Therefore, VEGFR-2 may be a new therapeutic target for liver regeneration. Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
URI
http://hdl.handle.net/20.500.11750/15477
DOI
10.21873/invivo.12400
Publisher
International Institute of Anticancer Research
Related Researcher
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Division of Biotechnology 1. Journal Articles

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