Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gwon, Kihak | - |
dc.contributor.author | Park, Jong-Deok | - |
dc.contributor.author | Lee, Seonhwa | - |
dc.contributor.author | Han, Ihn | - |
dc.contributor.author | Yu, Jong-Sung | - |
dc.contributor.author | Lee, Do Nam | - |
dc.date.accessioned | 2021-10-12T13:30:02Z | - |
dc.date.available | 2021-10-12T13:30:02Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/15480 | - |
dc.description.abstract | With the emergence of new drug-resistant microorganisms, the development of effective antimicrobial agents is urgently required. Core-shell-structured nanomaterials have received considerable attention as antibacterial agents. We prepared a bioactive core-shell-structured silicon-based NiOOH nanoflower (Si@NiOOH) targeted against various bacteria using a modified chemical bath deposition method. Further, we investigated its potential antibacterial mechanism by evaluating electrochemical properties in a redox reaction with ascorbic acid, measuring metal ion release, and analyzing the surface area. The bactericidal rate of Si@NiOOH at 200 μg/mL towards Pseudomonas aeruginosa, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus was as high as 99.9%. Si@NiOOH maintained its original morphology after killing the bacteria and exhibited negligible cytotoxicity towards mouse embryonic fibroblasts. The excellent antibacterial activities of Si@NiOOH are possibly derived from its high surface area, providing a wide active site attached to the cell wall, and the high oxidative potency of the Ni(III) cations existing on its surface. The high antibacterial activity and low cytotoxicity of the nanoflower make it a promising tool for promoting wound healing and for use with medical devices and implants. © 2021 The Korean Society of Industrial and Engineering Chemistry | - |
dc.language | English | - |
dc.publisher | 한국공업화학회 | - |
dc.title | Highly bioactive and low cytotoxic Si-based NiOOH nanoflowers targeted against various bacteria, including MRSA, and their potential antibacterial mechanism | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jiec.2021.04.038 | - |
dc.identifier.wosid | 000655693700012 | - |
dc.identifier.scopusid | 2-s2.0-85106229597 | - |
dc.identifier.bibliographicCitation | Journal of Industrial and Engineering Chemistry, v.99, pp.264 - 270 | - |
dc.identifier.kciid | ART002742544 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | Antibacterial activity | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Electrochemical property | - |
dc.subject.keywordAuthor | Mechanism | - |
dc.subject.keywordAuthor | Si-based nanoflower | - |
dc.subject.keywordAuthor | Surface area | - |
dc.subject.keywordPlus | Redox reactions | - |
dc.subject.keywordPlus | Shells (structures) | - |
dc.subject.keywordPlus | Silicon | - |
dc.subject.keywordPlus | Silicon compounds | - |
dc.subject.keywordPlus | Tissue regeneration | - |
dc.subject.keywordPlus | Anti-bacterial activity | - |
dc.subject.keywordPlus | Antibacterial mechanisms | - |
dc.subject.keywordPlus | Chemical bath deposition methods | - |
dc.subject.keywordPlus | Klebsiella pneumoniae | - |
dc.subject.keywordPlus | Low cytotoxicities | - |
dc.subject.keywordPlus | Methicillin-resistant staphylococcus aureus | - |
dc.subject.keywordPlus | Mouse embryonic fibroblasts | - |
dc.subject.keywordPlus | Pseudomonas aeruginosa | - |
dc.subject.keywordPlus | Nickel compounds | - |
dc.subject.keywordPlus | Antimicrobial agents | - |
dc.subject.keywordPlus | Ascorbic acid | - |
dc.subject.keywordPlus | Bacteria | - |
dc.subject.keywordPlus | Cell culture | - |
dc.subject.keywordPlus | Implants (surgical) | - |
dc.subject.keywordPlus | Metal ions | - |
dc.subject.keywordPlus | Metals | - |
dc.subject.keywordPlus | Morphology | - |
dc.subject.keywordPlus | Nanoflowers | - |
dc.citation.endPage | 270 | - |
dc.citation.startPage | 264 | - |
dc.citation.title | Journal of Industrial and Engineering Chemistry | - |
dc.citation.volume | 99 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry; Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary; Engineering, Chemical | - |
dc.type.docType | Article | - |
There are no files associated with this item.