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Olfactory neuropathology in Alzheimer's disease: a sign of ongoing neurodegeneration

Title
Olfactory neuropathology in Alzheimer's disease: a sign of ongoing neurodegeneration
Authors
Son, GowoonJahanshahi, AliYoo, Seung JunBoonstra, Jackson T.Hopkins, David A.Hendrik Wilhelm Maria SteinbuschMoon, Cheil
DGIST Authors
Son, Gowoon; Jahanshahi, Ali; Yoo, Seung Jun; Boonstra, Jackson T.; Hopkins, David A.; Hendrik Wilhelm Maria Steinbusch; Moon, Cheil
Issue Date
2021-06
Citation
BMB Reports, 54(6), 295-304
Type
Article
Author Keywords
Alzheimer&aposs diseaseOlfactory bulbOlfactory dysfunctionOlfactory epitheliumOlfactory sensory neuronPathophysiology
Keywords
ODOR IDENTIFICATIONSENSORY NEURONSAIR-FLOWBULBDYSFUNCTIONDECLINENASALBRAINMILD COGNITIVE IMPAIRMENTAMYLOID-BETA
ISSN
1976-6696
Abstract
Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory dysfunction is also associated with memory and cognitive dysfunction and is an incidental finding of AD dementia. Here we review neuropathological research on the olfactory system in AD, considering both structural and functional evidence. Experimental and clinical findings identify olfactory dysfunction as an early indicator of AD. In keeping with this, amyloid-beta production and neuroinflammation are related to underlying causes of impaired olfaction. Notably, physiological features of the spatial map in the olfactory system suggest the evidence of ongoing neurodegeneration. Our aim in this review is to examine olfactory pathology findings essential to identifying mechanisms of olfactory dysfunction in the development of AD in hopes of supporting investigations leading towards revealing potential diagnostic methods and causes of early pathogenesis in the olfactory system.
URI
http://hdl.handle.net/20.500.11750/15494
DOI
10.5483/bmbrep.2021.54.6.055
Publisher
생화학분자생물학회
Related Researcher
  • Author Moon, Cheil Laboratory of Chemical Senses
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
Department of Brain and Cognitive SciencesLaboratory of Chemical Senses1. Journal Articles


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