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Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy

Title
Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy
Authors
Kwon, Su-HyunFaruque, Hasan AlKee, HyeonwooKim, EunjooPark, Sukho
DGIST Authors
Kwon, Su-Hyun; Faruque, Hasan Al; Kee, Hyeonwoo; Kim, EunjooPark, Sukho
Issue Date
2021-09
Citation
Colloids and Surfaces B: Biointerfaces, 205, 111915
Type
Article
Author Keywords
Combined cancer therapyExosomeFolic acidHyperthermiaMagnetic nanoparticles
Keywords
DELIVERY VEHICLESCANCER-CELLSDOXORUBICINNANOPARTICLESRELEASE
ISSN
0927-7765
Abstract
Recently, natural exosomes have attracted attention as an ideal drug carrier to overcome the limitations of existing drug delivery systems which are toxicity induction and low cancer-targeting performance. In this study, we propose an exosome-based hybrid nanostructure (EHN) with improved targeting ability and therapeutic efficacy against colorectal cancer by using exosomes isolated from the tumor cell line as a drug carrier. The proposed EHN can have high biocompatibility by using exosomes, a biologically derived material, and show improved targeting performance by adding a tumor-targeting ligand (folic acid). In addition, the proposed EHN is capable of chemotherapy because doxorubicin, an anticancer drug, is encapsulated by the exosome with high efficiency, and it can induce hyperthermia therapy because of the magnetic nanoparticles (MNPs) attached to the surface of exosomes. Through in vitro and in vivo experiments using a xenograft tumor mouse model, it was confirmed that the proposed EHN could exhibit increased apoptosis and excellent tumor growth inhibition ability. Therefore, the proposed EHN is expected to overcome the limitations of existing drug delivery systems and be utilized as an effective drug delivery system in cancer treatment. © 2021 Elsevier B.V.
URI
http://hdl.handle.net/20.500.11750/15572
DOI
10.1016/j.colsurfb.2021.111915
Publisher
Elsevier BV
Related Researcher
  • Author Kim, Eunjoo  
  • Research Interests Biomarker, liquid biopsy, molecular diagnosis, nanobiosensor, drug delivery, exosome
Files:
There are no files associated with this item.
Collection:
Division of Electronics & Information System1. Journal Articles
Department of Robotics and Mechatronics EngineeringMultiscale Biomedical Robotics Laboratory1. Journal Articles


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