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PMP(Porphyrin-micelle-psma) nanoparticles for photoacoustic and ultrasound signal amplification in mouse prostate cancer xenografts

Title
PMP(Porphyrin-micelle-psma) nanoparticles for photoacoustic and ultrasound signal amplification in mouse prostate cancer xenografts
Author(s)
Kim , DaehyunHan, WonkookChang, Jin HoLee, Hak Jong
Issued Date
2021-10
Citation
Pharmaceutics, v.13, no.10
Type
Article
Author Keywords
Cancer diagnosisMicellePhotoacousticPorphyrinProstate cancerPSMA targetingUltrasound
Keywords
PHOTODYNAMIC THERAPYHORMONE-THERAPYPORPHYRINANTIGENPHOTOSENSITIZERSPSMACHEMOTHERAPYVERTEPORFINRADIATIONBIOMARKER
ISSN
1999-4923
Abstract
Photoacoustic (PA) imaging is used widely in cancer diagnosis. However, the availability of PA agents has not made great progress due to the limitations of the one currently in use, porphy-rin. Porphyrin–Micelle (PM), developed by synthesizing porphyrin and PEG-3.5k, confirmed the amplification of the PA agent signal, and added binding affinity in an LNCaP model by attaching prostate-specific membrane antigen PSMA. Compared to the previously used porphyrin, a superior signal was confirmed, and the potential of PMP was confirmed when it showed a signal superior to that of hemoglobin at the same concentration. In addition, in the in vivo mouse experiment, it was confirmed that the signal in the LNCaP xenograft model was stronger than that in the PC-3 xeno-graft model, and the PMP signal was about three times higher than that of PM and porphyrin. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/15752
DOI
10.3390/pharmaceutics13101636
Publisher
MDPI
Related Researcher
  • 장진호 Chang, Jin Ho
  • Research Interests Biomedical Imaging; Signal and Image Processing; Ultrasound Imaging System; Ultrasound Transducer; Photoacoustic Imaging
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Appears in Collections:
Department of Electrical Engineering and Computer Science Medical Acoustic Fusion Innovation Lab. 1. Journal Articles

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