Cited time in webofscience Cited time in scopus

Full metadata record

DC Field Value Language Kim, Dayea - Lee, Kwang Min - Lee, Chanhee - Jo, Yeon Suk - Muradillaevna, Muradillaeva Shakhnoza - Kim, Jae Ho - Yoon, Jong Hyuk - Song, Parkyong - 2021-12-02T13:30:03Z - 2021-12-02T13:30:03Z - 2021-11-25 - 2022-01 -
dc.identifier.issn 2212-4926 -
dc.identifier.uri -
dc.description.abstract Oxysterols are oxygenated cholesterol derivatives and important regulators of cholesterol metabolism, lipid homeostasis, the immune system, and membrane fluidity regulation. Although the detailed mechanism of action of oxysterols remains unclear, activation of some nuclear receptors, such as liver X receptor α (LXRα) and RAR-related orphan receptors, have been believed to be critical for the regulation of various physiological processes in multiple tissues. 27-Hydroxycholesterol (27-OHC) is an endogenous oxysterol, which has an intermediate function in cholesterol catabolism to bile acid synthesis. According to previous studies, however, there are opposing opinions on whether 27-OHC activates human LXR. Recently, several studies have shown that 27-OHC can activate or inhibit the function of estrogen receptors ERα and ERβ in a tissue-specific manner, indicating that the understanding of 27-OHC-mediated biological output is very complicated. This review summarizes the pathophysiological relevance of 27-OHC in various tissues, with a special discussion on their functions in human diseases. © 2021 Elsevier Ltd -
dc.language English -
dc.publisher Elsevier Ltd -
dc.title Pathophysiological role of 27-hydroxycholesterol in human diseases -
dc.type Article -
dc.identifier.doi 10.1016/j.jbior.2021.100837 -
dc.identifier.scopusid 2-s2.0-85119253835 -
dc.identifier.bibliographicCitation Advances in Biological Regulation, v.83 -
dc.description.isOpenAccess FALSE -
dc.subject.keywordAuthor Cardivascular disease -
dc.subject.keywordAuthor 27-Hydroxycholesterol -
dc.subject.keywordAuthor Brain disease -
dc.subject.keywordAuthor Cancer -
dc.subject.keywordAuthor Oxysterol -
dc.citation.title Advances in Biological Regulation -
dc.citation.volume 83 -
Files in This Item:

There are no files associated with this item.

Appears in Collections:
ETC 1. Journal Articles


  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.