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Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation

Title
Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation
Author(s)
Kweon, Hae-JinSuh, Byung-Chang
Issued Date
2013-06
Citation
BMB Reports, v.46, no.6, pp.295 - 304
Type
Article
Author Keywords
AcidosisAcid-sensing ion channelsG protein-coupled receptorsModulationPainpH
Keywords
MAMMALIAN SENSORY NEURONSCENTRAL-NERVOUS-SYSTEMROOT GANGLION NEURONSSPINAL-CORD NEURONSPHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATEARACHIDONIC-ACIDEXTRACELLULAR ACIDOSISMOLECULAR-MECHANISMSCEREBRAL-ISCHEMIARETINAL FUNCTION
ISSN
1976-6696
Abstract
Extracellular acidification occurs not only in pathological conditions such as inflammation and brain ischemia, but also in normal physiological conditions such as synaptic transmission. Acid-sensing ion channels (ASICs) can detect a broad range of physiological pH changes during pathological and synaptic cellular activities. ASICs are voltage-independent, proton-gated cation channels widely expressed throughout the central and peripheral nervous system. Activation of ASICs is involved in pain perception, synaptic plasticity, learning and memory, fear, ischemic neuronal injury, seizure termination, neuronal degeneration, and mechanosensation. Therefore, ASICs emerge as potential therapeutic targets for manipulating pain and neurological diseases. The activity of these channels can be regulated by many factors such as lactate, Zn2+, and Phe-Met-Arg-Phe amide (FMRFamide)-like neuropeptides by interacting with the channel's large extracellular loop. ASICs are also modulated by G protein-coupled receptors such as CB1 cannabinoid receptors and 5-HT2. This review focuses on the physiological roles of ASICs and the molecular mechanisms by which these channels are regulated. © 2013 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/1605
DOI
10.5483/BMBRep.2013.46.6.121
Publisher
Korean Society for Molecular and Cellular Biology
Related Researcher
  • 서병창 Suh, Byung-Chang
  • Research Interests Molecular mechanisms of epilepsy and sensory pain transmission; Signaling mechanism of ion channel regulation and membrane excitability; 분자전기생리; 간질 및 통증의 분자적 기전 연구
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Appears in Collections:
Department of Brain Sciences Laboratory of Brain Signal and Synapse Research 1. Journal Articles

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