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Closed-Loop Temperature-Controlled Magnetic Hyperthermia Therapy with Magnetic Guidance of Superparamagnetic Iron-Oxide Nanoparticles

Title
Closed-Loop Temperature-Controlled Magnetic Hyperthermia Therapy with Magnetic Guidance of Superparamagnetic Iron-Oxide Nanoparticles
Author(s)
Ahmed, AwaisKim, EunheeJeon, SungwoongKim, Jin-YoungChoi, Hongsoo
Issued Date
2022-02
Citation
Advanced Therapeutics, v.5, no.2
Type
Article
Author Keywords
superparamagnetic iron oxide nanoparticlesfeedback temperature controlmagnetic hyperthermiamagnetic manipulationcancer treatment
Keywords
FLUIDMOTION CONTROLMICROROBOTSAPOPTOSISSYSTEMTUMORS
ISSN
2366-3987
Abstract
Hyperthermia therapy eliminates cancer cells by heating them above physiological temperatures. Superparamagnetic iron oxide nanoparticles (SPIONs) are promising for targeted hyperthermia therapy because of their excellent heating efficiency, biocompatibility, and active magnetic navigation. When exposed to a high-frequency alternating magnetic field (AMF), SPIONs dissipate heat to damage cancer cells. Accurate temperature control is crucial for safe and efficient hyperthermia therapy. A closed-loop temperature controller to control the temperature and heating rate by adjusting AMF's strength, thereby enabling controllable hyperthermia therapy. Under a low-frequency rotating magnetic field (RMF), the SPIONs form chains which can be actively manipulated towards the target by adjusting RMF's direction, followed by AMF exposure for hyperthermia therapy. The SPIONs are precisely manipulated in a microfluidic chip and rat brain vessels ex vivo, highlighting the potential for targeted position control. Last, in vitro, and in vivo hyperthermia treatments are performed on human prostate cancer cells (PC3) and a PC3 xenograft mouse model using the proposed temperature controller, with tracking errors under 0.5 degrees C and significant reduction in cancer cell viability and tumor volume. The magnetic locomotion with RMF, and the controlled heating using AMF, show the feasibility of using SPIONs for targeted hyperthermia therapy. © 2022 Wiley-VCH GmbH
URI
http://hdl.handle.net/20.500.11750/16159
DOI
10.1002/adtp.202100237
Publisher
John Wiley and Sons Inc
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Appears in Collections:
Department of Robotics and Mechatronics Engineering Bio-Micro Robotics Lab 1. Journal Articles
Division of Biomedical Technology 1. Journal Articles

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