Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Sieun | - |
dc.contributor.author | Lee, Myungsun | - |
dc.contributor.author | Kim, Dong-Yoon | - |
dc.contributor.author | Son, Celine | - |
dc.contributor.author | Ahn, Benjamin Hyunju | - |
dc.contributor.author | Heo, Gyuryang | - |
dc.contributor.author | Park, Junkoo | - |
dc.contributor.author | Kim, Minyoo | - |
dc.contributor.author | Park, Han-Eol | - |
dc.contributor.author | Koo, Dong-Jun | - |
dc.contributor.author | Park, Jong Hwi | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Choe, Han Kyoung | - |
dc.contributor.author | Kim, Sung-Yon | - |
dc.date.accessioned | 2022-02-18T14:00:22Z | - |
dc.date.available | 2022-02-18T14:00:22Z | - |
dc.date.created | 2022-01-28 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/16220 | - |
dc.description.abstract | Thermoregulatory behavior is a basic motivated behavior for body temperature homeostasis. Despite its fundamental importance, a forebrain region or defined neural population required for this process has yet to be established. Here, we show that Vgat-expressing neurons in the lateral hypothalamus (LHVgat neurons) are required for diverse thermoregulatory behaviors. The population activity of LHVgat neurons is increased during thermoregulatory behavior and bidirectionally encodes thermal punishment and reward (P&R). Although this population also regulates feeding and caloric reward, inhibition of parabrachial inputs selectively impaired thermoregulatory behaviors and encoding of thermal stimulus by LHVgat neurons. Furthermore, two-photon calcium imaging revealed a subpopulation of LHVgat neurons bidirectionally encoding thermal P&R, which is engaged during thermoregulatory behavior, but is largely distinct from caloric reward-encoding LHVgat neurons. Our data establish LHVgat neurons as a required neural substrate for behavioral thermoregulation and point to the key role of the thermal P&R-encoding LHVgat subpopulation in thermoregulatory behavior. © 2021 Elsevier Inc. | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.title | A forebrain neural substrate for behavioral thermoregulation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.neuron.2021.09.039 | - |
dc.identifier.wosid | 000746053300002 | - |
dc.identifier.scopusid | 2-s2.0-85122801469 | - |
dc.identifier.bibliographicCitation | Neuron, v.110, no.2, pp.266 - 279.e9 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | reward and punishment | - |
dc.subject.keywordAuthor | thermal homeostasis | - |
dc.subject.keywordAuthor | thermal reward | - |
dc.subject.keywordAuthor | thermoregulatory behavior | - |
dc.subject.keywordAuthor | two-photon calcium imaging | - |
dc.subject.keywordAuthor | vesicular GABA transporter | - |
dc.subject.keywordAuthor | behavioral thermoregulation | - |
dc.subject.keywordAuthor | lateral hypothalamus | - |
dc.subject.keywordAuthor | motivated behavior | - |
dc.subject.keywordAuthor | parabrachial nucleus | - |
dc.subject.keywordPlus | LATERAL HYPOTHALAMIC-LESIONS | - |
dc.subject.keywordPlus | VENTRAL TEGMENTAL AREA | - |
dc.subject.keywordPlus | BODY-TEMPERATURE | - |
dc.subject.keywordPlus | THERMOSENSORY PATHWAY | - |
dc.subject.keywordPlus | PARABRACHIAL NUCLEUS | - |
dc.subject.keywordPlus | FEEDBACK-CONTROL | - |
dc.subject.keywordPlus | CELL-TYPES | - |
dc.subject.keywordPlus | CIRCUITS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | RATS | - |
dc.citation.endPage | 279.e9 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 266 | - |
dc.citation.title | Neuron | - |
dc.citation.volume | 110 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.type.docType | Article | - |
There are no files associated with this item.