Knockdown of Primary Ciliary Component Gene in Hypothalamic Paraventricular Nucleus Oxytocin Neurons Impairs Social Behavior
- Title
- Knockdown of Primary Ciliary Component Gene in Hypothalamic Paraventricular Nucleus Oxytocin Neurons Impairs Social Behavior
- Author(s)
- Seree Park
- DGIST Authors
- Seree Park ; Han Kyoung Choe ; Jeongyeon Kim
- Advisor
- 최한경
- Co-Advisor(s)
- Jeongyeon Kim
- Issued Date
- 2022
- Awarded Date
- 2022/02
- Type
- Thesis
- Description
- Oxytocin, Primary cilia, Ift88, Social recognition, Fiber photometry
- Table Of Contents
-
I. Introduction 1
II. Materials and Methods 3
III. Results 9
3.1 Knockdown of Ift88 in PVN-Oxt neurons with shRNA reduced cilia length 9
3.2 Adult-onset inhibition of ciliogenesis with shIft88 in PVN-Oxt neurons selectively disrupted social recognition and memory 10
3.3 Ift88 knockdown in adult PVN-Oxt neurons did not change metabolic phenotype 11
3.4 Postnatal Ift88 knockdown in PVN-Oxt neurons did not alter axonal projection 12
3.5 Ciliary dysgenesis in adult PVN-Oxt neurons increased spontaneous EPSCs 13
3.6 PVN-Oxt neurons are activated by social stimuli, especially on social novelty 14
3.7 Cilia mutant PVN-Oxt neurons showed different neuronal response 16
IV. Discussion 37
V. References 41
- URI
-
http://dgist.dcollection.net/common/orgView/200000593842
http://hdl.handle.net/20.500.11750/16298
- Degree
- Master
- Department
- Brain and Cognitive Sciences
- Publisher
- DGIST
- Related Researcher
-
-
Choe, Han Kyoung
- Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
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- Files in This Item:
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- Appears in Collections:
- Department of Brain Sciences Theses Master
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