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Knockdown of Primary Ciliary Component Gene in Hypothalamic Paraventricular Nucleus Oxytocin Neurons Impairs Social Behavior
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dc.contributor.advisor 최한경 -
dc.contributor.author Seree Park -
dc.date.accessioned 2022-03-07T16:00:25Z -
dc.date.available 2022-03-07T16:00:25Z -
dc.date.issued 2022 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200000593842 en_US
dc.identifier.uri http://hdl.handle.net/20.500.11750/16298 -
dc.description Oxytocin, Primary cilia, Ift88, Social recognition, Fiber photometry -
dc.description.statementofresponsibility N -
dc.description.tableofcontents I. Introduction 1
II. Materials and Methods 3
III. Results 9
3.1 Knockdown of Ift88 in PVN-Oxt neurons with shRNA reduced cilia length 9
3.2 Adult-onset inhibition of ciliogenesis with shIft88 in PVN-Oxt neurons selectively disrupted social recognition and memory 10
3.3 Ift88 knockdown in adult PVN-Oxt neurons did not change metabolic phenotype 11
3.4 Postnatal Ift88 knockdown in PVN-Oxt neurons did not alter axonal projection 12
3.5 Ciliary dysgenesis in adult PVN-Oxt neurons increased spontaneous EPSCs 13
3.6 PVN-Oxt neurons are activated by social stimuli, especially on social novelty 14
3.7 Cilia mutant PVN-Oxt neurons showed different neuronal response 16
IV. Discussion 37
V. References 41
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dc.format.extent 46 -
dc.language eng -
dc.publisher DGIST -
dc.subject Oxytocin, Primary cilia, Ift88, Social recognition, Fiber photometry -
dc.title Knockdown of Primary Ciliary Component Gene in Hypothalamic Paraventricular Nucleus Oxytocin Neurons Impairs Social Behavior -
dc.type Thesis -
dc.identifier.doi 10.22677/thesis.200000593842 -
dc.description.degree Master -
dc.contributor.department Brain and Cognitive Sciences -
dc.identifier.bibliographicCitation Seree Park. (2022). Knockdown of Primary Ciliary Component Gene in Hypothalamic Paraventricular Nucleus Oxytocin Neurons Impairs Social Behavior. doi: 10.22677/thesis.200000593842 -
dc.contributor.coadvisor Jeongyeon Kim -
dc.date.awarded 2022/02 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.BM 박54 202202 -
dc.date.accepted 1/21/22 -
dc.contributor.alternativeDepartment 뇌인지과학전공 -
dc.embargo.liftdate 20260228 -
dc.contributor.affiliatedAuthor Seree Park -
dc.contributor.affiliatedAuthor Han Kyoung Choe -
dc.contributor.affiliatedAuthor Jeongyeon Kim -
dc.contributor.alternativeName 박세리 -
dc.contributor.alternativeName Han Kyoung Choe -
dc.contributor.alternativeName 김정연 -
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