Oxytocin, Primary cilia, Ift88, Social recognition, Fiber photometry
Table Of Contents
I. Introduction 1 II. Materials and Methods 3 III. Results 9 3.1 Knockdown of Ift88 in PVN-Oxt neurons with shRNA reduced cilia length 9 3.2 Adult-onset inhibition of ciliogenesis with shIft88 in PVN-Oxt neurons selectively disrupted social recognition and memory 10 3.3 Ift88 knockdown in adult PVN-Oxt neurons did not change metabolic phenotype 11 3.4 Postnatal Ift88 knockdown in PVN-Oxt neurons did not alter axonal projection 12 3.5 Ciliary dysgenesis in adult PVN-Oxt neurons increased spontaneous EPSCs 13 3.6 PVN-Oxt neurons are activated by social stimuli, especially on social novelty 14 3.7 Cilia mutant PVN-Oxt neurons showed different neuronal response 16 IV. Discussion 37 V. References 41
