Cited 0 time in webofscience Cited 0 time in scopus

The effects of Compound ADX and Compound ADY in neuroinflammation phenotypes of Presenilin 2 N141I knock-in mouse

Title
The effects of Compound ADX and Compound ADY in neuroinflammation phenotypes of Presenilin 2 N141I knock-in mouse
Authors
Seohyeon Hwang
DGIST Authors
Seohyeon Hwang; Seong-Woon YuByung-Hoon Lee
Advisor(s)
유성운
Co-Advisor(s)
Byung-Hoon Lee
Issue Date
2022
Available Date
2022-03-08
Degree Date
2022/02
Type
Thesis
Keywords
Microglia, inflammation, Alzheimer disease (AD), Presenilin 2, Drug repositioning
Description
Microglia, inflammation, Alzheimer disease (AD), Presenilin 2, Drug repositioning
Table Of Contents
Ⅰ. Introduction 1 Ⅱ. Material and Methods 6 2.1 Mice 6 2.2 Cell culture 6 2.3 Reagents 7 2.4 Enzyme-linked immunosorbent assay (ELISA) 7 2.5 Cell death assay 7 2.6 Open field test 8 2.7 Y-maze assay 8 2.8 Aβ uptake and degradation 9 2.9 Phagocytosis Assay 9 2.10 Statistical analysis 10 Ⅲ. Results 11 3.1 Compound ADX and ADY reduce LPS-induced IL-6 production in Psen2 N141I/+ microglia 11 3.2 Compound ADX and ADY prevent LPS-induced memory deficit in Psen2 N141I/+ mice 14 3.3 Compound ADX and ADY rescue impaired degradation of fibril Aβ in Psen2 N141I/+ microglia 18 3.4 Compound ADX and ADY rescue the impaired phagocytosis ability in Psen2 N141I KI/+ microglia 22 Ⅳ. Discussion 26 Reference 28 Abstract in Korea 30
URI
http://dgist.dcollection.net/common/orgView/200000592247
http://hdl.handle.net/20.500.11750/16337
DOI
10.22677/thesis.200000592247
Degree
Master
Department
Brain and Cognitive Sciences
University
DGIST
Related Researcher
  • Author Yu, Seong-Woon Laboratory of Neuronal Cell Death
  • Research Interests Molecular mechanisms of neuronal cell death and neurodegeneration
Files:
There are no files associated with this item.
Collection:
Department of Brain SciencesThesesMaster


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE