The effects of Compound ADX and Compound ADY in neuroinflammation phenotypes of Presenilin 2 N141I knock-in mouse
- Title
- The effects of Compound ADX and Compound ADY in neuroinflammation phenotypes of Presenilin 2 N141I knock-in mouse
- Author(s)
- Seohyeon Hwang
- DGIST Authors
- Seohyeon Hwang ; Seong-Woon Yu ; Byung-Hoon Lee
- Advisor
- 유성운
- Co-Advisor(s)
- Byung-Hoon Lee
- Issued Date
- 2022
- Awarded Date
- 2022/02
- Type
- Thesis
- Description
- Microglia, inflammation, Alzheimer disease (AD), Presenilin 2, Drug repositioning
- Table Of Contents
-
Ⅰ. Introduction 1
Ⅱ. Material and Methods 6
2.1 Mice 6
2.2 Cell culture 6
2.3 Reagents 7
2.4 Enzyme-linked immunosorbent assay (ELISA) 7
2.5 Cell death assay 7
2.6 Open field test 8
2.7 Y-maze assay 8
2.8 Aβ uptake and degradation 9
2.9 Phagocytosis Assay 9
2.10 Statistical analysis 10
Ⅲ. Results 11
3.1 Compound ADX and ADY reduce LPS-induced IL-6 production in Psen2 N141I/+ microglia 11
3.2 Compound ADX and ADY prevent LPS-induced memory deficit in Psen2 N141I/+ mice 14
3.3 Compound ADX and ADY rescue impaired degradation of fibril Aβ in Psen2 N141I/+ microglia 18
3.4 Compound ADX and ADY rescue the impaired phagocytosis ability in Psen2 N141I KI/+ microglia 22
Ⅳ. Discussion 26
Reference 28
Abstract in Korea 30
- URI
-
http://dgist.dcollection.net/common/orgView/200000592247
http://hdl.handle.net/20.500.11750/16337
- Degree
- Master
- Department
- Brain and Cognitive Sciences
- Publisher
- DGIST
- Related Researcher
-
-
Yu, Seong-Woon
- Research Interests Molecular mechanisms of neuronal cell death and neurodegeneration
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- Files in This Item:
-
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- Appears in Collections:
- Department of Brain Sciences Theses Master
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