Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 유성운 | - |
| dc.contributor.author | Seohyeon Hwang | - |
| dc.date.accessioned | 2022-03-07T16:00:45Z | - |
| dc.date.available | 2022-03-07T16:00:45Z | - |
| dc.date.issued | 2022 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000592247 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/16337 | - |
| dc.description | Microglia, inflammation, Alzheimer disease (AD), Presenilin 2, Drug repositioning | - |
| dc.description.statementofresponsibility | N | - |
| dc.description.tableofcontents | Ⅰ. Introduction 1 Ⅱ. Material and Methods 6 2.1 Mice 6 2.2 Cell culture 6 2.3 Reagents 7 2.4 Enzyme-linked immunosorbent assay (ELISA) 7 2.5 Cell death assay 7 2.6 Open field test 8 2.7 Y-maze assay 8 2.8 Aβ uptake and degradation 9 2.9 Phagocytosis Assay 9 2.10 Statistical analysis 10 Ⅲ. Results 11 3.1 Compound ADX and ADY reduce LPS-induced IL-6 production in Psen2 N141I/+ microglia 11 3.2 Compound ADX and ADY prevent LPS-induced memory deficit in Psen2 N141I/+ mice 14 3.3 Compound ADX and ADY rescue impaired degradation of fibril Aβ in Psen2 N141I/+ microglia 18 3.4 Compound ADX and ADY rescue the impaired phagocytosis ability in Psen2 N141I KI/+ microglia 22 Ⅳ. Discussion 26 Reference 28 Abstract in Korea 30 |
- |
| dc.format.extent | 30 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.subject | Microglia, inflammation, Alzheimer disease (AD), Presenilin 2, Drug repositioning | - |
| dc.title | The effects of Compound ADX and Compound ADY in neuroinflammation phenotypes of Presenilin 2 N141I knock-in mouse | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/thesis.200000592247 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Brain and Cognitive Sciences | - |
| dc.contributor.coadvisor | Byung-Hoon Lee | - |
| dc.date.awarded | 2022/02 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BM 황54 202202 | - |
| dc.date.accepted | 1/21/22 | - |
| dc.contributor.alternativeDepartment | 뇌인지과학전공 | - |
| dc.embargo.liftdate | 20270228 | - |
| dc.contributor.affiliatedAuthor | Seohyeon Hwang | - |
| dc.contributor.affiliatedAuthor | Seong-Woon Yu | - |
| dc.contributor.affiliatedAuthor | Byung-Hoon Lee | - |
| dc.contributor.alternativeName | 황서현 | - |
| dc.contributor.alternativeName | Seong-Woon Yu | - |
| dc.contributor.alternativeName | 이병훈 | - |
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