Cited 2 time in webofscience Cited 2 time in scopus

Nano-patterned SU-8 surface using nanosphere-lithography for enhanced neuronal cell growth

Title
Nano-patterned SU-8 surface using nanosphere-lithography for enhanced neuronal cell growth
Authors
Kim, EunheeYoo, Seung-JunKim, EunjungKwon, Tae-HwanZhang, LiMoon, CheilChoi, Hongsoo
DGIST Authors
Moon, CheilChoi, Hongsoo
Issue Date
2016-04
Citation
Nanotechnology, 27(17)
Type
Article
Article Type
Article
Keywords
Amino AcidsCell CultureCell Culture MediumsCellsCytologyExtracellular MatricesImplants (Surgical)LithographyNano-PatternedNano-Scale SurfacesNano Sphere LithographyNanosphere Lithography (NSl)NanospheresNeurite OutgrowthNeuronal DevelopmentNeuronsPlastic CoatingsPolystyrene NanoparticlesSurface ModificationSurface Treatment
ISSN
0957-4484
Abstract
Mimicking the nanoscale surface texture of the extracellular matrix can affect the regulation of cellular behavior, including adhesion, differentiation, and neurite outgrowth. In this study, SU-8-based polymer surfaces with well-ordered nanowell arrays were fabricated using nanosphere lithography with polystyrene nanoparticles. We show that the SU-8 surface with nanowells resulted in similar neuronal development of rat pheochromocytoma (PC12) cells compared with an unpatterned poly-L-lysine (PLL)-coated SU-8 surface. Additionally, even after soaking the substrate in cell culture medium for two weeks, cells on the nanowell SU-8 surface showed long-term neurite outgrowth compared to cells on the PLL-coated SU-8 surface. The topographical surface modification of the nanowell array demonstrates potential as a replacement for cell adhesive material coatings such as PLL, for applications requiring long-term use of polymer-based implantable devices. © 2016 IOP Publishing Ltd.
URI
http://hdl.handle.net/20.500.11750/1643
DOI
10.1088/0957-4484/27/17/175303
Publisher
Institute of Physics Publishing
Related Researcher
  • Author Moon, Cheil Moon Lab
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles
Department of Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE