Cited 0 time in webofscience Cited 0 time in scopus

Identification of organophosphate modifications by high-resolution mass spectrometry

Title
Identification of organophosphate modifications by high-resolution mass spectrometry
Authors
Lee, Jun HyungJang, Wooyoung EricPark, JihwanMohammad, Hazara BegumLee, Jin-YoungJeong, Woo-HyeonKim, Min-Sik
DGIST Authors
Lee, Jun Hyung; Jang, Wooyoung Eric; Park, Jihwan; Mohammad, Hazara Begum; Lee, Jin-Young; Jeong, Woo-Hyeon; Kim, Min-Sik
Issue Date
2022-03
Citation
Bulletin of the Korean Chemical Society, 43(3), 444-449
Type
Article
Author Keywords
human plasmamass spectrometrynuerotoxicityorganophosphateprotein modification
Keywords
HUMAN SERUM-ALBUMINNERVE AGENTSEXPOSUREADDUCTSPESTICIDESBIOMARKER
ISSN
0253-2964
Abstract
Organophosphate (OP) compounds exhibit neurotoxicity by binding to serine residues of acetylcholinesterase (AChE) in the cholinergic nervous system and subsequently lead to the accumulation of acetylcholine in neuromuscular junctions of synapses. AChE capable of hydrolyzing choline esters is known to be inhibited in patients with nerve agents poisoning. Since OP is known to be transported by covalent bonding to human serum albumin (HSA), OP-HSA adducts are considered potential diagnostic markers for OP exposures. In this study, HSA modification sites by OP or OP-like compounds such as V-type (VX) and Novichok-type (A234), insecticide (DFP), and serine protease inhibitor (PMSF) were studied using liquid chromatography-high-resolution tandem mass spectrometry. As a result, we have discovered a novel OP-HSA modification site, Y341. © 2022 Korean Chemical Society, Seoul & Wiley-VCH GmbH
URI
http://hdl.handle.net/20.500.11750/16453
DOI
10.1002/bkcs.12478
Publisher
John Wiley and Sons Inc
Related Researcher
  • Author Kim, Min-Sik Laboratory for QBIO and Precision Medicine
  • Research Interests Cancer Proteogenomics, Biomarker Discovery, Integrative Multi-Omics
Files:
There are no files associated with this item.
Collection:
Department of New BiologyLaboratory for QBIO and Precision Medicine1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE