Title

Deletion of Phospholipase C eta 1 in habenula astrocyte induces depressive behavior

DGIST Authors

Jiyoung Lee ; Han Kyoung Choe ; Jeongyeon Kim

Advisor

최한경

Co-Advisor(s)

Jeongyeon Kim

Issued Date

2022

Awarded Date

2022/08

Citation

Jiyoung Lee. (2022). Deletion of Phospholipase C eta 1 in habenula astrocyte induces depressive behavior. doi: 10.22677/thesis.200000630783

Type

Thesis

Subject

Lateral habenula, Astrocyte, PLCη1, Depression

Description

Lateral habenula, Astrocyte, PLCη1, Depression

Abstract

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Table Of Contents

I. Introduction 1
II. Materials and Methods 7
III. Results 20
3.1 Deletion of PLCη1 in lateral habenula astrocyte with adeno-associated viral vector 20
3.2 PLCη1 in lateral habenula effect on depressive-like behavior 23
3.3 PLCη1 in lateral habenula did not effect the motor function and anxiety-like behavior 26
3.4 PLCη1 in lateral habenula did not alter working and fear memory 30
3.5 Deletion of astrocytic PLCη1disrupts tonic glutamate current in the LHb while sparing tonic GABA current 33
3.6 Impairment of extra synaptic long-term depression (LTD) in the deletion mice of astrocytic PLCη1 36
3.7 Astrocytic PLCη1 in lateral habenula disrupt synaptic function and regulate mood state 40
IV. Discussion 42
V. References 45

URI

http://dgist.dcollection.net/common/orgView/200000630783
http://hdl.handle.net/20.500.11750/16802

DOI

10.22677/thesis.200000630783

Degree

Master

Department

Department of Brain Sciences

Publisher

DGIST

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