Deletion of Phospholipase C eta 1 in habenula astrocyte induces depressive behavior
- Title
- Deletion of Phospholipase C eta 1 in habenula astrocyte induces depressive behavior
- Author(s)
- Jiyoung Lee
- DGIST Authors
- Jiyoung Lee ; Han Kyoung Choe ; Jeongyeon Kim
- Advisor
- 최한경
- Co-Advisor(s)
- Jeongyeon Kim
- Issued Date
- 2022
- Awarded Date
- 2022/08
- Type
- Thesis
- Description
- Lateral habenula, Astrocyte, PLCη1, Depression
- Abstract
- Table Of Contents
-
I. Introduction 1
II. Materials and Methods 7
III. Results 20
3.1 Deletion of PLCη1 in lateral habenula astrocyte with adeno-associated viral vector 20
3.2 PLCη1 in lateral habenula effect on depressive-like behavior 23
3.3 PLCη1 in lateral habenula did not effect the motor function and anxiety-like behavior 26
3.4 PLCη1 in lateral habenula did not alter working and fear memory 30
3.5 Deletion of astrocytic PLCη1disrupts tonic glutamate current in the LHb while sparing tonic GABA current 33
3.6 Impairment of extra synaptic long-term depression (LTD) in the deletion mice of astrocytic PLCη1 36
3.7 Astrocytic PLCη1 in lateral habenula disrupt synaptic function and regulate mood state 40
IV. Discussion 42
V. References 45
- URI
-
http://dgist.dcollection.net/common/orgView/200000630783
http://hdl.handle.net/20.500.11750/16802
- Degree
- Master
- Department
- Department of Brain Sciences
- Publisher
- DGIST
- Related Researcher
-
-
Choe, Han Kyoung
- Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
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- Files in This Item:
-
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- Appears in Collections:
- Department of Brain Sciences Theses Master
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