Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong Yu Sun | - |
dc.contributor.author | Huh, Sunghyun | - |
dc.contributor.author | Kim Ji Cheol | - |
dc.contributor.author | Park Ji Ye | - |
dc.contributor.author | Lee, ChaeEun | - |
dc.contributor.author | Kim, Min-Sik | - |
dc.contributor.author | Koo, JaeHyung | - |
dc.contributor.author | Bae Yoe-Sik | - |
dc.date.accessioned | 2022-10-25T00:30:01Z | - |
dc.date.available | 2022-10-25T00:30:01Z | - |
dc.date.created | 2022-09-23 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | BMB Reports, v.55, no.8, pp.395 - 400 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/16923 | - |
dc.description.abstract | Pseudomonas aeruginosa (P. aeruginosa) is a well-known Gramnegative opportunistic pathogen. Neutrophils play key roles in mediating host defense against P. aeruginosa infection. In this study, we identified a metabolite derived from P. aeruginosa that regulates neutrophil activities. Using gas chromatography-mass spectrometry, a markedly increased level of 2-undecanone was identified in the peritoneal fluid of P. aeruginosa-infected mice. 2-Undecanone elicited the activation of neutrophils in a Gαi-phospholipase C pathway. However, 2-undecanone strongly inhibited responses to lipopolysaccharide and bactericidal activity of neutrophils against P. aeruginosa by inducing apoptosis. Our results demonstrate that 2-undecanone from P. aeruginosa limits the innate defense activity of neutrophils, suggesting that the production of inhibitory metabolites is a strategy of P. aeruginosa for escaping the host immune system. [BMB Reports 2022; 55(8): 395-400] © 2022 by the The Korean Society for Biochemistry and Molecular Biology | - |
dc.language | English | - |
dc.publisher | Korean Society for Biochemistry and Molecular Biology | - |
dc.title | 2-Undecanone derived from Pseudomonas aeruginosa modulates the neutrophil activity | - |
dc.type | Article | - |
dc.identifier.doi | 10.5483/BMBRep.2022.55.8.009 | - |
dc.identifier.wosid | 000861372500005 | - |
dc.identifier.scopusid | 2-s2.0-85137135257 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | BMB Reports | - |
dc.identifier.kciid | ART002870435 | - |
dc.contributor.nonIdAuthor | Jeong Yu Sun | - |
dc.contributor.nonIdAuthor | Huh, Sunghyun | - |
dc.contributor.nonIdAuthor | Kim Ji Cheol | - |
dc.contributor.nonIdAuthor | Park Ji Ye | - |
dc.contributor.nonIdAuthor | Lee, ChaeEun | - |
dc.contributor.nonIdAuthor | Bae Yoe-Sik | - |
dc.identifier.citationVolume | 55 | - |
dc.identifier.citationNumber | 8 | - |
dc.identifier.citationStartPage | 395 | - |
dc.identifier.citationEndPage | 400 | - |
dc.identifier.citationTitle | BMB Reports | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | 2-undecanone | - |
dc.subject.keywordAuthor | Bacterial metabolite | - |
dc.subject.keywordAuthor | Neutrophil | - |
dc.subject.keywordAuthor | Pseudomonas aeruginosa | - |
dc.subject.keywordAuthor | Volatile organic compound | - |
dc.subject.keywordPlus | EXTRACELLULAR TRAPS | - |
dc.contributor.affiliatedAuthor | Jeong Yu Sun | - |
dc.contributor.affiliatedAuthor | Huh, Sunghyun | - |
dc.contributor.affiliatedAuthor | Kim Ji Cheol | - |
dc.contributor.affiliatedAuthor | Park Ji Ye | - |
dc.contributor.affiliatedAuthor | Lee, ChaeEun | - |
dc.contributor.affiliatedAuthor | Kim, Min-Sik | - |
dc.contributor.affiliatedAuthor | Koo, JaeHyung | - |
dc.contributor.affiliatedAuthor | Bae Yoe-Sik | - |
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