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A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability

Title
A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability
Author(s)
Noh, SeungminJeon, SungwoongKim, EunheeOh, UntaekPark, DanbiPark, Sun HwaKim, Sung WonPane, SalvadorNelson, Bradley J.Kim, Jin-youngChoi, Hongsoo
Issued Date
2022-06
Citation
Small, v.18, no.25
Type
Article
Author Keywords
biodegradationdroplet generationmagnetic actuationmicrorobotsstem cell delivery
Keywords
TARGETED DRUG-DELIVERYINTRANASAL DELIVERYNANOPARTICLESCYTOTOXICITYFABRICATIONTURBINATE
ISSN
1613-6810
Abstract
A great deal of research has focused on small-scale robots for biomedical applications and minimally invasive delivery of therapeutics (e.g., cells, drugs, and genes) to a target area. Conventional fabrication methods, such as two-photon polymerization, can be used to build sophisticated micro- and nanorobots, but the long fabrication cycle for a single microrobot has limited its practical use. This study proposes a biodegradable spherical gelatin methacrylate (GelMA) microrobot for mass production in a microfluidic channel. The proposed microrobot is fabricated in a flow-focusing droplet generator by shearing a mixture of GelMA, photoinitiator, and superparamagnetic iron oxide nanoparticles (SPIONs) with a mixture of oil and surfactant. Human nasal turbinate stem cells (hNTSCs) are loaded on the GelMA microrobot, and the hNTSC-loaded microrobot shows precise rolling motion in response to an external rotating magnetic field. The microrobot is enzymatically degraded by collagenase, and released hNTSCs are proliferated and differentiated into neuronal cells. In addition, the feasibility of the GelMA microrobot as a cell therapeutic delivery system is investigated by measuring electrophysiological activity on a multielectrode array. Such a versatile and fully biodegradable microrobot has the potential for targeted stem cell delivery, proliferation, and differentiation for stem cell-based therapy.
URI
http://hdl.handle.net/20.500.11750/17149
DOI
10.1002/smll.202107888
Publisher
Wiley - V C H Verlag GmbbH & Co.
Related Researcher
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Appears in Collections:
Department of Robotics and Mechatronics Engineering Bio-Micro Robotics Lab 1. Journal Articles
Division of Biomedical Technology 1. Journal Articles

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