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Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana

Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana
Khare, D.[Khare, Deepa]Mitsuda, N.[Mitsuda, Nobukata]Lee, S.[Lee, Seung Chul]Song, W.-Y.[Song, Won Yong]Hwang, D.[Hwang, Dae Hee]Ohme-Takagi, M.[Ohme Takagi, Masaru]Martinoia, E.[Martinoia, Enrico]Lee, Y.[Lee, Young Sook]Hwang, J.-U.[Hwang, Jae Ung]
DGIST Authors
Hwang, D.[Hwang, Dae Hee]
Issue Date
New Phytologist, 213(3), 1257-1273
Article Type
Article in Press
Arabidopsis ThalianaCadmium (Cd)Copper (Cu)GLABRA1 ENHANCER BINDING PROTEIN (GeBP) Transcription FactorOxidative StressReactive Oxygen Species (ROS)Root AvoidanceSplit Media AssayZinc (Zn)
Plants reorganize their root architecture to avoid growth into unfavorable regions of the rhizosphere. In a screen based on chimeric repressor gene-silencing technology, we identified the Arabidopsis thaliana GeBP-LIKE 4 (GPL4) transcription factor as an inhibitor of root growth that is induced rapidly in root tips in response to cadmium (Cd). We tested the hypothesis that GPL4 functions in the root avoidance of Cd by analyzing root proliferation in split medium, in which only half of the medium contained toxic concentrations of Cd. The wild-type (WT) plants exhibited root avoidance by inhibiting root growth in the Cd side but increasing root biomass in the control side. By contrast, GPL4-suppression lines exhibited nearly comparable root growth in the Cd and control sides and accumulated more Cd in the shoots than did the WT. GPL4 suppression also altered the root avoidance of toxic concentrations of other essential metals, modulated the expression of many genes related to oxidative stress, and consistently decreased reactive oxygen species concentrations. We suggest that GPL4 inhibits the growth of roots exposed to toxic metals by modulating reactive oxygen species concentrations, thereby allowing roots to colonize noncontaminated regions of the rhizosphere. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust
Blackwell Publishing Ltd
Related Researcher
  • Author Hwang, Dae Hee Systems Biology and Medicine Lab
  • Research Interests Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
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Department of New BiologySystems Biology and Medicine Lab1. Journal Articles

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