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Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)

Title
Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)
Author(s)
Lee, Tae HeeCha, Sun-ShinLee, Chang-SeopRhee, Joon HaengWoo, Hye RyunChung, Kyung Min
Issued Date
2016-11
Citation
Microbiology and Immunology, v.60, no.11, pp.793 - 800
Type
Article
Author Keywords
cross-protectionMARTX toxinmonoclonal antibodyVibrio species
Keywords
ACCESSORY TOXINSAUTOPROCESSING RTX TOXINB-SUBUNITCross-ProtectionCYSTEINE PROTEASE DOMAINEL-TORMartx ToxinMiceMonoclonal AntibodyMOUSE MODELPATHOGENESISVACCINEVibrio SpeciesVIRULENCE
ISSN
0385-5600
Abstract
Gram-negative Vibrio species secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins associated with bacterial pathogenesis. Here, the cross-reactivity and cross-protectivity of mAbs against V. vulnificus RtxA1/MARTXVv was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal V. cholerae infection. Interestingly, 24RA and 46RA, which map to the cysteine protease domain of V. cholerae MARTXVc, inhibited CPD autocleavage in vitro; this process is involved in V. cholerae pathogenesis. These results generate new insight into the development of broadly protective mAbs and/or vaccines against Vibrio species with MARTX toxins. © 2016 The Societies and John Wiley & Sons Australia, Ltd
URI
http://hdl.handle.net/20.500.11750/2163
DOI
10.1111/1348-0421.12449
Publisher
Wiley Blackwell
Related Researcher
  • 우혜련 Woo, Hye Ryun
  • Research Interests Genome biology; Epigenomics; Plant senescence
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Appears in Collections:
Department of New Biology CBRG(Complex Biology Research Group) 1. Journal Articles
Department of New Biology Lab of Plant Molecular Communication 1. Journal Articles

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