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dc.contributor.author Yeo, Bo Kyoung -
dc.contributor.author Yu, Seong-Woon -
dc.date.available 2017-07-05T08:47:26Z -
dc.date.created 2017-04-10 -
dc.date.issued 2016-11 -
dc.identifier.issn 1976-8354 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/2310 -
dc.description.abstract Valosin-containing protein (VCP) is a hexameric protein belonging to the type II AAA+ (ATPases Associated with diverse cellular Activities) protein family. VCP governs multiple cellular processes and its diverse functions are determined by its interaction with a wide variety of partners and cofactors. Recently, mutations in VCP were suggested to cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia, amyotrophic lateral sclerosis, and Huntington’s disease. However, the pathogenic mechanisms of VCP mutations in these diseases are still largely unknown. In this review, we summarize the structure and cellular functions of VCP, especially focusing on apoptosis and two major cellular degradation pathways, the ubiquitin–proteasome system and autophagy. We also list the representative VCP mutations and discuss their potential association with neurodegenerative diseases. © 2016 Korean Society for Integrative Biology. -
dc.language English -
dc.publisher Taylor and Francis Ltd. -
dc.title Valosin-containing protein (VCP): structure, functions, and implications in neurodegenerative diseases -
dc.type Article -
dc.identifier.doi 10.1080/19768354.2016.1259181 -
dc.identifier.scopusid 2-s2.0-85000770465 -
dc.identifier.bibliographicCitation Animal Cells and Systems, v.20, no.6, pp.303 - 309 -
dc.identifier.kciid ART002186191 -
dc.description.isOpenAccess FALSE -
dc.subject.keywordAuthor Valosin-containing protein -
dc.subject.keywordAuthor autophagy -
dc.subject.keywordAuthor apoptosis -
dc.subject.keywordAuthor Ubiquitin–proteasome system -
dc.subject.keywordAuthor neurodegenerative disease -
dc.subject.keywordPlus AAA-ATPASE -
dc.subject.keywordPlus APOPTOSIS -
dc.subject.keywordPlus Autophagy -
dc.subject.keywordPlus Bone -
dc.subject.keywordPlus DEATH -
dc.subject.keywordPlus FRONTOTemPORAL DemENTIA -
dc.subject.keywordPlus HUNTINGTONS-DISEASE -
dc.subject.keywordPlus Insulin Withdrawal -
dc.subject.keywordPlus MUTATIONS -
dc.subject.keywordPlus MYOPATHY -
dc.subject.keywordPlus NEURAL STem-CELLS -
dc.subject.keywordPlus Neurodegenerative Disease -
dc.subject.keywordPlus PAGET-DISEASE -
dc.subject.keywordPlus UBIQUITIN-PROTEASOME System -
dc.subject.keywordPlus Valosin-Containing Protein -
dc.citation.endPage 309 -
dc.citation.number 6 -
dc.citation.startPage 303 -
dc.citation.title Animal Cells and Systems -
dc.citation.volume 20 -
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Department of Brain Sciences Laboratory of Neuronal Cell Death 1. Journal Articles

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