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Vascular-Inducing Poly(glycolic acid)-Collagen Nanocomposite-Fiber Scaffold
- Vascular-Inducing Poly(glycolic acid)-Collagen Nanocomposite-Fiber Scaffold
- Kobayashi, H[Kobayashi, Hisatoshi]; Terada, D[Terada, Dohiko]; Yokoyama, Y[Yokoyama, Yoshiro]; Moon, DW[Moon, Dae Won]; Yasuda, Y[Yasuda, Yoshihiro]; Koyama, H[Koyama, Hiroyuki]; Takato, T[Takato, Tsuyoshi]
- DGIST Authors
- Moon, DW[Moon, Dae Won]
- Issue Date
- Journal of Biomedical Nanotechnology, 9(8), 1318-1326
- Article Type
- Angiogenesis; Angiogenesis Inducing Agents; Animal Cell; Animals; Basic Fibroblast Growth Factor; Biodegradable; Blood Vessels; Body Fluid; Cell Culture; Cells, Cultured; Chemical Structure; Coated Materials, Biocompatible; Collagen; Decomposition; Degradation Kinetics; Electric Potential; Endothelial Cells; Endothelium Cell; Fibroblast; Fibroblast Growth Factor 2; Flow Rate; Fragmentation Reaction; Host Cell; Implantation; Inflammation; Macrophage; Male; Mice; Models, Biological; Molecular Scaffold; Nanocomposite; Nanocomposite Nanofibers; Nanocomposites; Nanofiber; Nanofibers; Nanomaterial; Neo-Vascularization (Pathology); Neo-Vascularization, Physiologic; Non-Human; Peripheral Blood Vessels; Phagocytosis; Poly Glycolic Acid; Polyglycolic Acid; Rats; Rats, Wistar; Regenerative Medicine; Scaffolds (Biology); Structure Analysis; Swine; Tissue Engineering; Tissue Scaffolds; Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A; Vascularization
- For regenerative medicine with scaffolds, the immediate cellularization of the scaffold accompanied by angiogenesis inside is an important event. Such the aim is generally pursued by combining basic fibroblast growth factor (b-FGF) or vascular endothelial growth factor (VEGF) with the scaffold. In this study, we produced the nanocomposite nanofiber composed of poly(glycolic acid), PGA, and collagen to accomplish the recruitment of host cells and peripheral blood vessels without the bio-derived matter like growth factors. Structural analysis revealed that the fiber has the sheath-core like structure in which the surface region is abundant in PGA and the core region is abundant in collagen. This peculiar fibrous structure probably contributes the fragility of the fiber under the swelling in body fluid. The results of the animal experiment demonstrated that the PGA-collagen nanofiber sponge was entirely populated and vascularized within 5 days after the implantation. We hypothesized that the early fragmentation of the implanted fibrous sponge accelerated the host's inflammation reaction by phagocytized by macrophage, which followed by the recruitment of the fibroblasts and endothelial cells from the host tissue. Designing the suitable nanoscale structure of materials makes cellularization and vascularization of the scaffold possible without bio-derived factors. Copyright © 2013 American Scientific Publishers All rights reserved.
- American Scientific Publishers
- Related Researcher
Moon, Dae Won
NanoBio Imaging Laboratory
Coherent Raman Scattering; Surface Plasmon Resonance Imaging Ellipsometry; Imaging Mass Spectrometry; Time-of-flight Medium Energy Ion Scattering
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- Department of New BiologyNanoBio Imaging Laboratory1. Journal Articles
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