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Vascular-Inducing Poly(glycolic acid)-Collagen Nanocomposite-Fiber Scaffold

Vascular-Inducing Poly(glycolic acid)-Collagen Nanocomposite-Fiber Scaffold
Kobayashi, H[Kobayashi, Hisatoshi]Terada, D[Terada, Dohiko]Yokoyama, Y[Yokoyama, Yoshiro]Moon, DW[Moon, Dae Won]Yasuda, Y[Yasuda, Yoshihiro]Koyama, H[Koyama, Hiroyuki]Takato, T[Takato, Tsuyoshi]
DGIST Authors
Moon, DW[Moon, Dae Won]
Issued Date
Article Type
AngiogenesisAngiogenesis Inducing AgentsAnimal CellAnimalsBasic Fibroblast Growth FactorBiodegradableBlood VesselsBody FluidCell CultureCells, CulturedChemical StructureCoated Materials, BiocompatibleCollagenDecompositionDegradation KineticsElectric PotentialEndothelial CellsEndothelium CellFibroblastFibroblast Growth Factor 2Flow RateFragmentation ReactionHost CellImplantationInflammationMacrophageMaleMiceModels, BiologicalMolecular ScaffoldNanocompositeNanocomposite NanofibersNanocompositesNanofiberNanofibersNanomaterialNeo-Vascularization (Pathology)Neo-Vascularization, PhysiologicNon-HumanPeripheral Blood VesselsPhagocytosisPoly Glycolic AcidPolyglycolic AcidRatsRats, WistarRegenerative MedicineScaffolds (Biology)Structure AnalysisSwineTissue EngineeringTissue ScaffoldsVascular Endothelial Growth FactorVascular Endothelial Growth Factor AVascularization
For regenerative medicine with scaffolds, the immediate cellularization of the scaffold accompanied by angiogenesis inside is an important event. Such the aim is generally pursued by combining basic fibroblast growth factor (b-FGF) or vascular endothelial growth factor (VEGF) with the scaffold. In this study, we produced the nanocomposite nanofiber composed of poly(glycolic acid), PGA, and collagen to accomplish the recruitment of host cells and peripheral blood vessels without the bio-derived matter like growth factors. Structural analysis revealed that the fiber has the sheath-core like structure in which the surface region is abundant in PGA and the core region is abundant in collagen. This peculiar fibrous structure probably contributes the fragility of the fiber under the swelling in body fluid. The results of the animal experiment demonstrated that the PGA-collagen nanofiber sponge was entirely populated and vascularized within 5 days after the implantation. We hypothesized that the early fragmentation of the implanted fibrous sponge accelerated the host's inflammation reaction by phagocytized by macrophage, which followed by the recruitment of the fibroblasts and endothelial cells from the host tissue. Designing the suitable nanoscale structure of materials makes cellularization and vascularization of the scaffold possible without bio-derived factors. Copyright © 2013 American Scientific Publishers All rights reserved.
American Scientific Publishers
Related Researcher
  • 문대원 Moon, Dae Won
  • Research Interests Coherent Raman Scattering; Surface Plasmon Resonance Imaging Ellipsometry; Imaging Mass Spectrometry; Time-of-flight Medium Energy Ion Scattering
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Department of New Biology NanoBio Imaging Laboratory 1. Journal Articles


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