Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Hyunjung | - |
dc.contributor.author | Jang, Yong Ho | - |
dc.contributor.author | Cho, Ik-Hyun | - |
dc.contributor.author | Yu, Seong-Woon | - |
dc.contributor.author | Lee, Sung Joong | - |
dc.date.available | 2017-07-11T04:38:39Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2544 | - |
dc.description.abstract | Background: Intracerebral hemorrhage (ICH) is one of the major causes of stroke. After onset of ICH, massive infiltration of macrophages is detected in the peri-hematoma regions. Still, the function of these macrophages in ICH has not been completely elucidated. Results: In a collagenase-induced ICH model, CX3CR1+ macrophages accumulated in the peri-hematoma region. Characterization of these macrophages revealed expression of alternatively activated (M2) macrophage markers. In the macrophage-depleted mice, ICH-induced brain lesion volume was larger and neurological deficits were more severe compared to those of control mice, indicating a protective role of these macrophages in ICH. In the ICH-injured brain, mannose receptor-expressing macrophages increased at a delayed time point after ICH, indicating M2 polarization of the brain-infiltrating macrophages in the brain microenvironment. To explore this possibility, bone marrow-derived macrophages (BMDM) were co-cultured with mouse brain glial cells and then tested for activation phenotype. Upon co-culture with glia, the number of mannose receptor-positive M2 macrophages was significantly increased. Furthermore, treatment with glia-conditioned media increased the number of BMDM of M2 phenotype. Conclusions: In this study, our data suggest that brain-infiltrating macrophages after ICH are polarized to the M2 phenotype by brain glial cells and thereby contribute to recovery from ICH injury. © 2016 Min et al. | - |
dc.language | English | - |
dc.publisher | BioMed Central Ltd. | - |
dc.title | Alternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13041-016-0225-3 | - |
dc.identifier.scopusid | 2-s2.0-84966331203 | - |
dc.identifier.bibliographicCitation | Molecular Brain, v.9 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | Immune response | - |
dc.subject.keywordAuthor | Macrophages | - |
dc.subject.keywordAuthor | Wound healing | - |
dc.subject.keywordPlus | Animal Cell | - |
dc.subject.keywordPlus | Animal Experiment | - |
dc.subject.keywordPlus | Animal Model | - |
dc.subject.keywordPlus | Animal Tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | Bioaccumulation | - |
dc.subject.keywordPlus | Bone Marrow Derived Macrophage | - |
dc.subject.keywordPlus | Brain Cell | - |
dc.subject.keywordPlus | Brain Damage | - |
dc.subject.keywordPlus | Brain Hemorrhage | - |
dc.subject.keywordPlus | Brain Injury | - |
dc.subject.keywordPlus | Brain Protection | - |
dc.subject.keywordPlus | Cell Count | - |
dc.subject.keywordPlus | Cell Polarity | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | Chemokine Receptor CX3CR1 | - |
dc.subject.keywordPlus | Coculture | - |
dc.subject.keywordPlus | Collagenase | - |
dc.subject.keywordPlus | Controlled Study | - |
dc.subject.keywordPlus | CX3CR1+ Macrophage | - |
dc.subject.keywordPlus | DIFFERENTIAL REGULATION | - |
dc.subject.keywordPlus | Disease Severity | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | Glia Cell | - |
dc.subject.keywordPlus | hematoma | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | Immune Response | - |
dc.subject.keywordPlus | INFLAMMATORY MEDIATORS | - |
dc.subject.keywordPlus | Macrophage | - |
dc.subject.keywordPlus | MACROPHAGE ACTIVATION | - |
dc.subject.keywordPlus | Macrophage Function | - |
dc.subject.keywordPlus | Macrophage Migration | - |
dc.subject.keywordPlus | Macrophages | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Mannose Receptor | - |
dc.subject.keywordPlus | Microglia | - |
dc.subject.keywordPlus | Mouse | - |
dc.subject.keywordPlus | Neurologic Disease | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Phenotype | - |
dc.subject.keywordPlus | Polarization | - |
dc.subject.keywordPlus | Priority Journal | - |
dc.subject.keywordPlus | Protein Expression | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | SPINAL-CORD-INJURY | - |
dc.subject.keywordPlus | TUMOR-ASSOCIATED MACROPHAGES | - |
dc.subject.keywordPlus | Wound Healing | - |
dc.citation.title | Molecular Brain | - |
dc.citation.volume | 9 | - |