Cited time in webofscience Cited time in scopus

ADP-ribosylation Factor 6 (ARF6) Bidirectionally Regulates Dendritic Spine Formation Depending on Neuronal Maturation and Activity

Title
ADP-ribosylation Factor 6 (ARF6) Bidirectionally Regulates Dendritic Spine Formation Depending on Neuronal Maturation and Activity
Author(s)
Kim, YoonjuLee, Sang-EunPark, JoohyunKim, MinhyungLee, BoyoonHwang, DaeheeChang, Sunghoe
Issued Date
2015-03
Citation
Journal of Biological Chemistry, v.290, no.12, pp.7323 - 7335
Type
Article
Author Keywords
ADP-ribosylation Factor (ARF)Dendritic SpinePhospholipase DRas-related C3 Botulinum Toxin Substrate 1 (Rac1)Synaptic PlasticityARF6Rac1Neuronal Activity
Keywords
CULTURED HIPPOCAMPAL-NEURONSNUCLEOTIDE EXCHANGE FACTORSSYNAPTIC PLASTICITYPLASMA-MEMBRANECEREBRAL-CORTEXGTPASERACACTIVATIONSTABILITYFILOPODIA
ISSN
0021-9258
Abstract
Recent studies have reported conflicting results regarding the role of ARF6 in dendritic spine development, but no clear answer for the controversy has been suggested. We found that ADP-ribosylation factor 6 (ARF6) either positively or negatively regulates dendritic spine formation depending on neuronal maturation and activity. ARF6 activation increased the spine formation in developing neurons, whereas it decreased spine density in mature neurons. Genome-wide microarray analysis revealed that ARF6 activation in each stage leads to opposite patterns of expression of a subset of genes that are involved in neuronal morphology. ARF6-mediated Rac1 activation via the phospholipase D pathway is the coincident factor in both stages, but the antagonistic RhoA pathway becomes involved in the mature stage. Furthermore, blocking neuronal activity in developing neurons using tetrodotoxin or enhancing the activity in mature neurons using picrotoxin or chemical long term potentiation reversed the effect of ARF6 on each stage. Thus, activity-dependent dynamic changes in ARF6-mediated spine structures may play a role in structural plasticity of mature neurons. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
URI
http://hdl.handle.net/20.500.11750/2606
DOI
10.1074/jbc.M114.634527
Publisher
American Society for Biochemistry and Molecular Biology Inc.
Files in This Item:
000351613600001.pdf

000351613600001.pdf

기타 데이터 / 4.2 MB / Adobe PDF download
Appears in Collections:
Department of New Biology Systems Biology and Medicine Lab 1. Journal Articles

qrcode

  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE