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dc.contributor.author Lee, Kyung-Ah ko
dc.contributor.author Kim, Boram ko
dc.contributor.author Bhin, Jinhyuk ko
dc.contributor.author Kim, Do Hun ko
dc.contributor.author You, Hyejin ko
dc.contributor.author Kim, Eun-Kyoung ko
dc.contributor.author Kim, Sung-Hee ko
dc.contributor.author Ryu, Ji-Hwan ko
dc.contributor.author Hwang, Daehee ko
dc.contributor.author Lee, Won-Jae ko
dc.date.available 2017-07-11T04:43:21Z -
dc.date.created 2017-04-10 -
dc.date.issued 2015-02 -
dc.identifier.citation Cell Host and Microbe, v.17, no.2, pp.191 - 204 -
dc.identifier.issn 1931-3128 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/2609 -
dc.description.abstract Genetic studies in Drosophila have demonstrated that generation of microbicidal reactive oxygen species (ROS) through the NADPH dual oxidase (DUOX) is a first line of defense in the gut epithelia. Bacterial uracil acts as DUOX-activating ligand through poorly understood mechanisms. Here, we show that the Hedgehog (Hh) signaling pathway modulates uracil-induced DUOX activation. Uracil-induced Hh signaling is required for intestinal expression of the calcium-dependent cell adhesion molecule Cadherin 99C (Cad99C) and subsequent Cad99C-dependent formation of endosomes. These endosomes play essential roles in uracil-induced ROS production by acting as signaling platforms for PLCβ/PKC/Ca2+-dependent DUOX activation. Animals with impaired Hh signaling exhibit abolished Cad99C-dependent endosome formation and reduced DUOX activity, resulting in high mortality during enteric infection. Importantly, endosome formation, DUOX activation, and normal host survival are restored by genetic reintroduction of Cad99C into enterocytes, demonstrating the important role for Hh signaling in host resistance to enteric infection. © 2015 Elsevier Inc. -
dc.language English -
dc.publisher Cell Press -
dc.title Bacterial Uracil Modulates Drosophila DUOX-Dependent Gut Immunity via Hedgehog-Induced Signaling Endosomes -
dc.type Article -
dc.identifier.doi 10.1016/j.chom.2014.12.012 -
dc.identifier.wosid 000349761700009 -
dc.identifier.scopusid 2-s2.0-84922935450 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.contributor.nonIdAuthor Lee, Kyung-Ah -
dc.contributor.nonIdAuthor Kim, Boram -
dc.contributor.nonIdAuthor Bhin, Jinhyuk -
dc.contributor.nonIdAuthor Kim, Do Hun -
dc.contributor.nonIdAuthor You, Hyejin -
dc.contributor.nonIdAuthor Kim, Eun-Kyoung -
dc.contributor.nonIdAuthor Kim, Sung-Hee -
dc.contributor.nonIdAuthor Ryu, Ji-Hwan -
dc.contributor.nonIdAuthor Lee, Won-Jae -
dc.identifier.citationVolume 17 -
dc.identifier.citationNumber 2 -
dc.identifier.citationStartPage 191 -
dc.identifier.citationEndPage 204 -
dc.identifier.citationTitle Cell Host and Microbe -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.contributor.affiliatedAuthor Hwang, Daehee -
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