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DC Field Value Language Lee, Kyung-Ah ko Kim, Boram ko Bhin, Jinhyuk ko Kim, Do Hun ko You, Hyejin ko Kim, Eun-Kyoung ko Kim, Sung-Hee ko Ryu, Ji-Hwan ko Hwang, Daehee ko Lee, Won-Jae ko 2017-07-11T04:43:21Z - 2017-04-10 - 2015-02 -
dc.identifier.citation Cell Host and Microbe, v.17, no.2, pp.191 - 204 -
dc.identifier.issn 1931-3128 -
dc.identifier.uri -
dc.description.abstract Genetic studies in Drosophila have demonstrated that generation of microbicidal reactive oxygen species (ROS) through the NADPH dual oxidase (DUOX) is a first line of defense in the gut epithelia. Bacterial uracil acts as DUOX-activating ligand through poorly understood mechanisms. Here, we show that the Hedgehog (Hh) signaling pathway modulates uracil-induced DUOX activation. Uracil-induced Hh signaling is required for intestinal expression of the calcium-dependent cell adhesion molecule Cadherin 99C (Cad99C) and subsequent Cad99C-dependent formation of endosomes. These endosomes play essential roles in uracil-induced ROS production by acting as signaling platforms for PLCβ/PKC/Ca2+-dependent DUOX activation. Animals with impaired Hh signaling exhibit abolished Cad99C-dependent endosome formation and reduced DUOX activity, resulting in high mortality during enteric infection. Importantly, endosome formation, DUOX activation, and normal host survival are restored by genetic reintroduction of Cad99C into enterocytes, demonstrating the important role for Hh signaling in host resistance to enteric infection. © 2015 Elsevier Inc. -
dc.language English -
dc.publisher Cell Press -
dc.title Bacterial Uracil Modulates Drosophila DUOX-Dependent Gut Immunity via Hedgehog-Induced Signaling Endosomes -
dc.type Article -
dc.identifier.doi 10.1016/j.chom.2014.12.012 -
dc.identifier.wosid 000349761700009 -
dc.identifier.scopusid 2-s2.0-84922935450 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.contributor.nonIdAuthor Lee, Kyung-Ah -
dc.contributor.nonIdAuthor Kim, Boram -
dc.contributor.nonIdAuthor Bhin, Jinhyuk -
dc.contributor.nonIdAuthor Kim, Do Hun -
dc.contributor.nonIdAuthor You, Hyejin -
dc.contributor.nonIdAuthor Kim, Eun-Kyoung -
dc.contributor.nonIdAuthor Kim, Sung-Hee -
dc.contributor.nonIdAuthor Ryu, Ji-Hwan -
dc.contributor.nonIdAuthor Lee, Won-Jae -
dc.identifier.citationVolume 17 -
dc.identifier.citationNumber 2 -
dc.identifier.citationStartPage 191 -
dc.identifier.citationEndPage 204 -
dc.identifier.citationTitle Cell Host and Microbe -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.contributor.affiliatedAuthor Hwang, Daehee -
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Department of New Biology Systems Biology and Medicine Lab 1. Journal Articles


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