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dc.contributor.author Kim, Jeongsik -
dc.contributor.author Kim, Jin Hee -
dc.contributor.author Richards, Eric J. -
dc.contributor.author Chung, Kyung Min -
dc.contributor.author Woo, Hye Ryun -
dc.date.available 2017-07-11T05:25:48Z -
dc.date.created 2017-04-10 -
dc.date.issued 2014-09 -
dc.identifier.citation Molecular Plant, v.7, no.9, pp.1470 - 1485 -
dc.identifier.issn 1674-2052 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/2646 -
dc.description.abstract Methylcytosine-binding proteins containing SRA (SET- and RING-Associated) domain are required for the establishment and/or maintenance of DNA methylation in both plants and animals. We previously proposed that Arabidopsis VIM/ORTH proteins with an SRA domain maintain DNA methylation and epigenetic gene silencing in heterochromatic regions. However, their endogenous targets of epigenetic gene silencing have not been analyzed globally and the mechanisms by which VIM proteins coordinate DNA methylation and epigenetic silencing are largely unknown. In this study, a genome-wide transcript profiling analysis revealed 544 derepressed genes in a vim1/2/3 triple mutant, including 133 known genes. VIM1 bound to promoter and transcribed regions of the up-regulated genes in vim1/2/3 and VIM deficiency caused severe DNA hypomethylation in all sequence contexts at direct VIM1 targets. We found a drastic loss of H3K9me2 at heterochromatic chromocenters in vim1/2/3 nuclei. Furthermore, aberrant changes in transcriptionally active and repressive histone modifications were observed at VIM1 targets in vim1/2/3. VIM1-binding capacity to target genes was significantly reduced in the met1 background, indicating that VIM1 primarily recognizes CG methylation deposited by MET1. Overall, our data indicate that VIM proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation and histone modification status in collaboration with MET1. © 2014 The Authors. All rights reserved. -
dc.publisher Cell Press -
dc.title Arabidopsis VIM Proteins Regulate Epigenetic Silencing by Modulating DNA Methylation and Histone Modification in Cooperation with MET1 -
dc.type Article -
dc.identifier.doi 10.1093/mp/ssu079 -
dc.identifier.wosid 000342930000007 -
dc.identifier.scopusid 2-s2.0-84927172064 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Molecular Plant -
dc.contributor.nonIdAuthor Kim, Jeongsik -
dc.contributor.nonIdAuthor Kim, Jin Hee -
dc.contributor.nonIdAuthor Richards, Eric J. -
dc.contributor.nonIdAuthor Chung, Kyung Min -
dc.identifier.citationVolume 7 -
dc.identifier.citationNumber 9 -
dc.identifier.citationStartPage 1470 -
dc.identifier.citationEndPage 1485 -
dc.identifier.citationTitle Molecular Plant -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.contributor.affiliatedAuthor Kim, Jeongsik -
dc.contributor.affiliatedAuthor Kim, Jin Hee -
dc.contributor.affiliatedAuthor Richards, Eric J. -
dc.contributor.affiliatedAuthor Chung, Kyung Min -
dc.contributor.affiliatedAuthor Woo, Hye Ryun -
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Department of New Biology Lab of Plant Molecular Communication 1. Journal Articles

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