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DC Field Value Language Kim, Su-Jin - Chae, Sehyun - Kim, Hokeun - Mun, Dong-Gi - Back, Seunghoon - Choi, Hye Yeon - Park, Kyong Soo - Hwang, Daehee - Choi, Sung Hee - Lee, Sang-Won - 2017-07-11T05:26:53Z - 2017-04-10 - 2014-03 -
dc.identifier.citation Molecular and Cellular Proteomics, v.13, no.3, pp.811 - 822 -
dc.identifier.issn 1535-9476 -
dc.identifier.uri -
dc.description.abstract Adipose tissue is increasingly recognized as an endocrine organ playing important pathophysiological roles in metabolic abnormalities, such as obesity, cardiovascular disease, and type 2 diabetes mellitus (T2DM). In particular, visceral adipose tissue (VAT), as opposed to subcutaneous adipose tissue, is closely linked to the pathogenesis of insulin resistance and T2DM. Despite the importance of VAT, its molecular signatures related to the pathogenesis of T2DM have not been systematically explored. Here, we present comprehensive proteomic analysis of VATs in drug-naïve early T2DM patients and subjects with normal glucose tolerance. A total of 4,707 proteins were identified in LC-MS/MS experiments. Among them, 444 increased in abundance in T2DM and 328 decreased. They are involved in T2DM-related processes including inflammatory responses, peroxisome proliferator-activated receptor signaling, oxidative phosphorylation, fatty acid oxidation, and glucose metabolism. Of these proteins, we selected 11 VAT proteins that can represent alteration in early T2DM patients. Among them, up-regulation of FABP4, C1QA, S100A8, and SORBS1 and down-regulation of ACADL and PLIN4 were confirmed in VAT samples of independent early T2DM patients using Western blot. In summary, our profiling provided a comprehensive basis for understanding the link of a protein profile of VAT to early pathogenesis of T2DM. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. -
dc.publisher American Society for Biochemistry and Molecular Biology Inc. -
dc.title A Protein Profile of Visceral Adipose Tissues Linked to Early Pathogenesis of Type 2 Diabetes Mellitus -
dc.type Article -
dc.identifier.doi 10.1074/mcp.M113.035501 -
dc.identifier.wosid 000332391100009 -
dc.identifier.scopusid 2-s2.0-84895556114 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Molecular and Cellular Proteomics -
dc.contributor.nonIdAuthor Kim, Su-Jin -
dc.contributor.nonIdAuthor Chae, Sehyun -
dc.contributor.nonIdAuthor Kim, Hokeun -
dc.contributor.nonIdAuthor Mun, Dong-Gi -
dc.contributor.nonIdAuthor Back, Seunghoon -
dc.contributor.nonIdAuthor Choi, Hye Yeon -
dc.contributor.nonIdAuthor Park, Kyong Soo -
dc.contributor.nonIdAuthor Hwang, Daehee -
dc.contributor.nonIdAuthor Choi, Sung Hee -
dc.contributor.nonIdAuthor Lee, Sang-Won -
dc.identifier.citationVolume 13 -
dc.identifier.citationNumber 3 -
dc.identifier.citationStartPage 811 -
dc.identifier.citationEndPage 822 -
dc.identifier.citationTitle Molecular and Cellular Proteomics -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.contributor.affiliatedAuthor Kim, Su-Jin -
dc.contributor.affiliatedAuthor Chae, Sehyun -
dc.contributor.affiliatedAuthor Kim, Hokeun -
dc.contributor.affiliatedAuthor Mun, Dong-Gi -
dc.contributor.affiliatedAuthor Back, Seunghoon -
dc.contributor.affiliatedAuthor Choi, Hye Yeon -
dc.contributor.affiliatedAuthor Park, Kyong Soo -
dc.contributor.affiliatedAuthor Hwang, Daehee -
dc.contributor.affiliatedAuthor Choi, Sung Hee -
dc.contributor.affiliatedAuthor Lee, Sang-Won -


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