Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Ryu, Jae Ryun | - |
dc.contributor.author | Hong, Caroline Jeeyeon | - |
dc.contributor.author | Kim, Joo Yeon | - |
dc.contributor.author | Kim, Eun-Kyoung | - |
dc.contributor.author | Sun, Woong | - |
dc.contributor.author | Yu, Seong-Woon | - |
dc.date.available | 2017-07-11T05:32:41Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2694 | - |
dc.description.abstract | The presence of neural stem cells (NSCs) and the production of new neurons in the adult brain have received great attention from scientists and the public because of implications to brain plasticity and their potential use for treating currently incurable brain diseases. Adult neurogenesis is controlled at multiple levels, including proliferation, differentiation, migration, and programmed cell death (PCD). Among these, PCD is the last and most prominent process for regulating the final number of mature neurons integrated into neural circuits. PCD can be classified into apoptosis, necrosis, and autophagic cell death and emerging evidence suggests that all three may be important modes of cell death in neural stem/progenitor cells. However, the molecular mechanisms that regulate PCD and thereby impact the intricate balance between self-renewal, proliferation, and differentiation during adult neurogenesis are not well understood. In this comprehensive review, we focus on the extent, mechanism, and biological significance of PCD for the control of adult neurogenesis in the mammalian brain. The role of intrinsic and extrinsic factors in the regulation of PCD at the molecular and systems levels is also discussed. Adult neurogenesis is a dynamic process, and the signals for differentiation, proliferation, and death of neural progenitor/stem cells are closely interrelated. A better understanding of how adult neurogenesis is influenced by PCD will help lead to important insights relevant to brain health and diseases. © 2016 Ryu et al. | - |
dc.language | English | - |
dc.publisher | BioMed Central Ltd. | - |
dc.title | Control of adult neurogenesis by programmed cell death in the mammalian brain | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13041-016-0224-4 | - |
dc.identifier.wosid | 000374675100001 | - |
dc.identifier.scopusid | 2-s2.0-84966340354 | - |
dc.identifier.bibliographicCitation | Molecular Brain, v.9, no.1 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | Adult neurogenesis | - |
dc.subject.keywordAuthor | Programmed cell death | - |
dc.subject.keywordAuthor | Neural stem cells | - |
dc.subject.keywordAuthor | Neuroblasts | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Necrosis | - |
dc.subject.keywordPlus | Adult Neurogenesis | - |
dc.subject.keywordPlus | AGE-RELATED DECLINE | - |
dc.subject.keywordPlus | Aging | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | Autophagy | - |
dc.subject.keywordPlus | Brain Injury | - |
dc.subject.keywordPlus | Brain Ischemia | - |
dc.subject.keywordPlus | Cell Isolation | - |
dc.subject.keywordPlus | Cell Migration | - |
dc.subject.keywordPlus | Cell Proliferation | - |
dc.subject.keywordPlus | Cell Renewal | - |
dc.subject.keywordPlus | DE-NOVO NEUROGENESIS | - |
dc.subject.keywordPlus | Energy Metabolism | - |
dc.subject.keywordPlus | Fas Antigen | - |
dc.subject.keywordPlus | Hippocampus | - |
dc.subject.keywordPlus | Human | - |
dc.subject.keywordPlus | Intracellular Signaling | - |
dc.subject.keywordPlus | LONG-TERM SURVIVAL | - |
dc.subject.keywordPlus | MEDIATED GENE-TRANSFER | - |
dc.subject.keywordPlus | Necrosis | - |
dc.subject.keywordPlus | Neocortex | - |
dc.subject.keywordPlus | Nerve Cell Differentiation | - |
dc.subject.keywordPlus | Nerve Cell Necrosis | - |
dc.subject.keywordPlus | Nerve Cell Network | - |
dc.subject.keywordPlus | NERVE GROWTH-FACTOR | - |
dc.subject.keywordPlus | NEURAL STem-CELLS | - |
dc.subject.keywordPlus | Neural Stem Cell | - |
dc.subject.keywordPlus | Neural Stem Cells | - |
dc.subject.keywordPlus | Neuroblast | - |
dc.subject.keywordPlus | Neuroblasts | - |
dc.subject.keywordPlus | NEWLY GENERATED NEURONS | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Olfactory Bulb | - |
dc.subject.keywordPlus | Priority Journal | - |
dc.subject.keywordPlus | Programmed Cell Death | - |
dc.subject.keywordPlus | RAT DENTATE GYRUS | - |
dc.subject.keywordPlus | Retina Ganglion Cell | - |
dc.subject.keywordPlus | Review | - |
dc.subject.keywordPlus | ROSTRAL MIGRATORY STREAM | - |
dc.subject.keywordPlus | Scatter Factor | - |
dc.subject.keywordPlus | Stem Cell Transplantation | - |
dc.subject.keywordPlus | SUBCORTICAL WHITE-MATTER | - |
dc.subject.keywordPlus | Subventricular Zone | - |
dc.subject.keywordPlus | Tumor Necrosis Factor Alpha | - |
dc.subject.keywordPlus | Tumor Necrosis Factor Related Apoptosis Inducing Ligand | - |
dc.citation.number | 1 | - |
dc.citation.title | Molecular Brain | - |
dc.citation.volume | 9 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.type.docType | Review | - |