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Electrochemical detection of nanomolar dopamine in the presence of neurophysiological concentration of ascorbic acid and uric acid using charge-coated carbon nanotubes via facile and green preparation
- Electrochemical detection of nanomolar dopamine in the presence of neurophysiological concentration of ascorbic acid and uric acid using charge-coated carbon nanotubes via facile and green preparation
- Oh, JW[Oh, Jeong-Wook]; Yoon, YW[Yoon, Yeo Woon]; Heo, J[Heo, Jihye]; Yu, J[Yu, Joonhee]; Kim, H[Kim, Hasuck]; Kim, TH[Kim, Tae Hyun]
- DGIST Authors
- Kim, H[Kim, Hasuck]
- Issue Date
- Talanta, 147, 453-459
- Article Type
- Amines; Ascorbic Acid; Carbon; Carbon Nanotube; Carbon Nanotubes; Chemical Detection; Chemistry; Citric Acid; Cyclic Voltammetry; Diagnosis; Differential Pulse Voltammetry; Dopamine; Electro-Chemical Electrodes; Electrocatalytic Effects; Electrocatalytic Properties; Electrochemical Analysis; Electrochemical Detection; Electrochemical Determination; Electrochemical Techniques; Electrode; Electrodes; Glassy Carbon; Glassy Carbon Electrodes; Green Chemistry; Green Chemistry Technology; Infrared Spectroscopy; Microscopy, Electron, Scanning; Multiwalled Carbon Nanotubes (MWCN); Nanotubes; Nanotubes, Carbon; Neurophysiology; Organic Acids; Polyethyleneimine; Scanning Electron Microscopy; Sonication; Spectroscopy, Fourier Transform Infrared; Ultrastructure; Uric Acid; Uric Acids; Voltammetry; Yarn
- Negatively charged multi-walled carbon nanotubes (MWCNTs) were prepared using simple sonication technique with non-toxic citric acid (CA) for the electrochemical detection of dopamine (DA). CA/MWCNTs were placed on glassy carbon (GC) electrodes by drop-casting method and then electrochemical determinations of DA were performed in the presence of highly concentrated ascorbic acid (AA). For the comparison of the charge effect on MWCNTs surface, positively charged polyethyleneimine (PEI)/MWCNT/GC electrode and pristine MWCNT/GC electrode were also prepared. Contrary to conventional GC electrode, all three types of MWCNT modified electrodes (CA/MWCNT/GC, PEI/MWCNT/GC, and pristine MWCNT/GC) can discriminate ~μM of DA from 1 mM AA using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) due to the inherent electrocatalytic effect of MWCNTs. Compared to positively charged PEI/MWCNT/GC and pristine MWCNT/GC electrodes, negatively charged CA/MWCNT/GC electrode remarkably enhanced the electrochemical sensitivity and selectivity of DA, showing the linear relationship between DPV signal and DA concentration in the range of 10-1000 nM even in the presence of ~105 times concentrated AA, which is attributed to the synergistic effect of the electrostatic interaction between cationic DA molecules and negatively charged MWCNTs and the inherent electrocatalytic property of MWCNT. As a result, the limit of detection (LOD) of DA for CA/MWCNT/GC electrode was 4.2 nM, which is 5.2 and 16.5 times better than those for MWCNT/GC electrode and PEI/MWCNT/GC electrode even in the presence of 1 mM AA. This LOD value for DA at CA/MWCNT/GC electrode is one of the lowest values compared to the previous reports and is low enough for the early diagnosis of neurological disorder in the presence of physiological AA concentration (~0.5 mM). In addition, the high selectivity and sensitivity of DA at CA/MWCNT/GC electrode were well kept even in the presence of both 1 mM AA and 10 μM uric acid (UA) as similar as neurophysiological concentration. © 2015 Elsevier B.V. All rights reserved.
- Elsevier B.V.
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