Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Oh, Tae Seok | - |
dc.contributor.author | Cho, Hanchae | - |
dc.contributor.author | Cho, Jae Hyun | - |
dc.contributor.author | Yu, Seong-Woon | - |
dc.contributor.author | Kim, Eun-Kyoung | - |
dc.date.available | 2017-07-11T05:39:49Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2779 | - |
dc.description.abstract | Hypothalamic AMP-activated protein kinase (AMPK) plays important roles in the regulation of food intake by altering the expression of orexigenic or anorexigenic neuropeptides. However, little is known about the mechanisms of this regulation. Here, we report that hypothalamic AMPK modulates the expression of NPY (neuropeptide Y), an orexigenic neuropeptide, and POMC (pro-opiomelanocortin-α), an anorexigenic neuropeptide, by regulating autophagic activity in vitro and in vivo. In hypothalamic cell lines subjected to low glucose availability such as 2-deoxy-d-glucose (2DG)-induced glucoprivation or glucose deprivation, autophagy was induced via the activation of AMPK, which regulates ULK1 and MTOR complex 1 followed by increased Npy and decreased Pomc expression. Pharmacological or genetic inhibition of autophagy diminished the effect of AMPK on neuropeptide expression in hypothalamic cell lines. Moreover, AMPK knockdown in the arcuate nucleus of the hypothalamus decreased autophagic activity and changed Npy and Pomc expression, leading to a reduction in food intake and body weight. AMPK knockdown abolished the orexigenic effects of intraperitoneal 2DG injection by decreasing autophagy and changing Npy and Pomc expression in mice fed a high-fat diet. We suggest that the induction of autophagy is a possible mechanism of AMPK-mediated regulation of neuropeptide expression and control of feeding in response to low glucose availability. © 2016 Taylor & Francis. | - |
dc.publisher | Taylor and Francis Inc. | - |
dc.title | Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/15548627.2016.1215382 | - |
dc.identifier.scopusid | 2-s2.0-84994112554 | - |
dc.identifier.bibliographicCitation | Autophagy, v.12, no.11, pp.2009 - 2025 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | appetite | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | glucoprivation | - |
dc.subject.keywordAuthor | glucose deprivation | - |
dc.subject.keywordAuthor | hypothalamic AMPK | - |
dc.subject.keywordAuthor | neuropeptide | - |
dc.subject.keywordPlus | UNC 51 Like Kinase 1 | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | AGRP NEURONS | - |
dc.subject.keywordPlus | Animal Cell | - |
dc.subject.keywordPlus | Animal Experiment | - |
dc.subject.keywordPlus | Appetite | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | Autophagy | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | Cell Line | - |
dc.subject.keywordPlus | COMPOUND C | - |
dc.subject.keywordPlus | Controlled Study | - |
dc.subject.keywordPlus | Deoxyglucose | - |
dc.subject.keywordPlus | Down Regulation | - |
dc.subject.keywordPlus | ENERGY-BALANCE | - |
dc.subject.keywordPlus | Enzyme Activation | - |
dc.subject.keywordPlus | Enzyme Inhibition | - |
dc.subject.keywordPlus | Enzyme Phosphorylation | - |
dc.subject.keywordPlus | FATTY-ACID | - |
dc.subject.keywordPlus | Food Intake | - |
dc.subject.keywordPlus | Glucoprivation | - |
dc.subject.keywordPlus | GLUCOSE-HOMEOSTASIS | - |
dc.subject.keywordPlus | GLUCOSE DEPRIVATION | - |
dc.subject.keywordPlus | Hydroxymethylglutaryl Coenzyme A Reductase Kinase | - |
dc.subject.keywordPlus | Hyperphagia | - |
dc.subject.keywordPlus | Hypothalamic Ampk | - |
dc.subject.keywordPlus | Hypothalamus | - |
dc.subject.keywordPlus | Hypothalamus Nucleus | - |
dc.subject.keywordPlus | In Vitro Study | - |
dc.subject.keywordPlus | In Vivo Study | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | MAMMALIAN TARGET | - |
dc.subject.keywordPlus | Mammalian Target of Rapamycin Complex 1 | - |
dc.subject.keywordPlus | Mouse | - |
dc.subject.keywordPlus | Neuropeptide | - |
dc.subject.keywordPlus | Neuropeptide Y | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Proopiomelanocortin | - |
dc.subject.keywordPlus | Protein Expression | - |
dc.subject.keywordPlus | Protein Serine Threonine Kinase | - |
dc.subject.keywordPlus | RAT HYPOTHALAMUS | - |
dc.subject.keywordPlus | Unclassified Drug | - |
dc.subject.keywordPlus | Weight Reduction | - |
dc.citation.endPage | 2025 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2009 | - |
dc.citation.title | Autophagy | - |
dc.citation.volume | 12 | - |
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