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Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

Title
Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy
Author(s)
Kim, Hyun-ChulKim, EunjooJeong, Sang WonHa, Tae-LinPark, Sang-ImLee, Se GuenLee, Sung JunLee, Seung Woo
Issued Date
2015
Citation
Nanoscale, v.7, no.39, pp.16470 - 16480
Type
Article
Keywords
BLOCK-COPOLYMER MICELLESCONTROLLED DRUG-RELEASECANCER-THERAPYDELIVERYNANOCAPSULESCIRCULATIONTOXICITYVEHICLESPLATFORM
ISSN
2040-3364
Abstract
Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia. © The Royal Society of Chemistry.
URI
http://hdl.handle.net/20.500.11750/2977
DOI
10.1039/c5nr04130a
Publisher
Royal Society of Chemistry
Related Researcher
  • 김현철 Kim, Hyun-Chul
  • Research Interests Nanomedicine; Polymer Drug Conjugates; Drug Delivery System
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Appears in Collections:
Division of Biomedical Technology 1. Journal Articles
Division of AI, Big data and Block chain 1. Journal Articles

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